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10.1101/2021.05.10.21256423 http://scihub22266oqcxt.onion/10.1101/2021.05.10.21256423 34013287!8132261!34013287     free     free     free Deprecated: Implicit conversion from float 235.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 235.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 235.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 235.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 235.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 235.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 269.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       medRxiv 2021 ; ä (ä): ä Nephropedia Template TP {{tp|p=34013287|t=2021. Insights into genetic factors contributing to variability in SARS-CoV-2 susceptibility and COVID-19 disease severity |pdf=|usr=}}{{34013287}} gab.com Text Insights into genetic factors contributing to variability in SARS-CoV-2 susceptibility and COVID-19 disease severity JO: medRxiv http://www.kidney.de/pget.php?&tw=1&pmid=34013287 #FOAvip Variability in SARS-CoV-2 susceptibility and COVID-19 disease severity between individuals is partly due to genetic factors. Here, we applied colocalization to compare summary statistics for 16 GWASs from the COVID-19 Host Genetics Initiative to investigate similarities and differences in their genetic signals. We identified 9 loci associated with susceptibility (one with two independent GWAS signals; one with an ethnicity-specific signal), 14 associated with severity (one with two independent GWAS signals; two with ethnicity-specific signals) and one harboring two discrepant GWAS signals (one for susceptibility; one for severity). Utilizing colocalization we also identified 45 GTEx tissues that had eQTL(s) for 18 genes strongly associated with GWAS signals in eleven loci (1-4 genes per locus). Some of these genes showed tissue-specific altered expression and others showed altered expression in up to 41 different tissue types. Our study provides insights into the complex molecular mechanisms underlying inherited predispositions to COVID-19-disease phenotypes. Twit Text FOAVip Insights into genetic factors contributing to variability in SARS-CoV-2 susceptibility and COVID-19 disease severity ????medRxiv http://www.kidney.de/pget.php?&tw=1&pmid=34013287 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=34013287 #FOAvip English Wikipedia <ref>{{Cite pmid|34013287}}</ref> Insights into genetic factors contributing to variability in SARS-CoV-2 susceptibility and COVID-19 disease severity #MMPMID34013287 D'Antonio M; Arthur TD; Nguyen JP; Matsui H; D'Antonio-Chronowska A; Frazer KA medRxiv 2021[May]; ä (ä): ä PMID34013287show ga Variability in SARS-CoV-2 susceptibility and COVID-19 disease severity between individuals is partly due to genetic factors. Here, we applied colocalization to compare summary statistics for 16 GWASs from the COVID-19 Host Genetics Initiative to investigate similarities and differences in their genetic signals. We identified 9 loci associated with susceptibility (one with two independent GWAS signals; one with an ethnicity-specific signal), 14 associated with severity (one with two independent GWAS signals; two with ethnicity-specific signals) and one harboring two discrepant GWAS signals (one for susceptibility; one for severity). Utilizing colocalization we also identified 45 GTEx tissues that had eQTL(s) for 18 genes strongly associated with GWAS signals in eleven loci (1-4 genes per locus). Some of these genes showed tissue-specific altered expression and others showed altered expression in up to 41 different tissue types. Our study provides insights into the complex molecular mechanisms underlying inherited predispositions to COVID-19-disease phenotypes. äInsights into genetic factors contributing to variability in SARS-CoV-(epmc).pdf DeepDyve Pubget Overpricing