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10.1038/s41598-021-89957-z http://scihub22266oqcxt.onion/10.1038/s41598-021-89957-z 34012108!8134500!34012108     free     free     free Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Sci+Rep 2021 ; 11 (1): 10617 Nephropedia Template TP {{tp|p=34012108|t=2021. A super-potent tetramerized ACE2 protein displays enhanced neutralization of SARS-CoV-2 virus infection |pdf=|usr=}}{{34012108}} gab.com Text A super-potent tetramerized ACE2 protein displays enhanced neutralization of SARS-CoV-2 virus infection JO: Sci Rep http://www.kidney.de/pget.php?&tw=1&pmid=34012108 #FOAvip Approaches are needed for therapy of the severe acute respiratory syndrome from SARS-CoV-2 coronavirus (COVID-19). Interfering with the interaction of viral antigens with the angiotensin converting enzyme 2 (ACE-2) receptor is a promising strategy by blocking the infection of the coronaviruses into human cells. We have implemented a novel protein engineering technology to produce a super-potent tetravalent form of ACE2, coupled to the human immunoglobulin gamma1 Fc region, using a self-assembling, tetramerization domain from p53 protein. This high molecular weight Quad protein (ACE2-Fc-TD) retains binding to the SARS-CoV-2 receptor binding spike protein and can form a complex with the spike protein plus anti-viral antibodies. The ACE2-Fc-TD acts as a powerful decoy protein that out-performs soluble monomeric and dimeric ACE2 proteins and blocks both SARS-CoV-2 pseudovirus and SARS-CoV-2 virus infection with greatly enhanced efficacy. The ACE2 tetrameric protein complex promise to be important for development as decoy therapeutic proteins against COVID-19. In contrast to monoclonal antibodies, ACE2 decoy is unlikely to be affected by mutations in SARS-CoV-2 that are beginning to appear in variant forms. In addition, ACE2 multimeric proteins will be available as therapeutic proteins should new coronaviruses appear in the future because these are likely to interact with ACE2 receptor. Twit Text FOAVip A super-potent tetramerized ACE2 protein displays enhanced neutralization of SARS-CoV-2 virus infection ????Sci Rep http://www.kidney.de/pget.php?&tw=1&pmid=34012108 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=34012108 #FOAvip English Wikipedia <ref>{{Cite pmid|34012108}}</ref> A super-potent tetramerized ACE2 protein displays enhanced neutralization of SARS-CoV-2 virus infection #MMPMID34012108 Miller A; Leach A; Thomas J; McAndrew C; Bentley E; Mattiuzzo G; John L; Mirazimi A; Harris G; Gamage N; Carr S; Ali H; Van Montfort R; Rabbitts T Sci Rep 2021[May]; 11 (1): 10617 PMID34012108show ga Approaches are needed for therapy of the severe acute respiratory syndrome from SARS-CoV-2 coronavirus (COVID-19). Interfering with the interaction of viral antigens with the angiotensin converting enzyme 2 (ACE-2) receptor is a promising strategy by blocking the infection of the coronaviruses into human cells. We have implemented a novel protein engineering technology to produce a super-potent tetravalent form of ACE2, coupled to the human immunoglobulin gamma1 Fc region, using a self-assembling, tetramerization domain from p53 protein. This high molecular weight Quad protein (ACE2-Fc-TD) retains binding to the SARS-CoV-2 receptor binding spike protein and can form a complex with the spike protein plus anti-viral antibodies. The ACE2-Fc-TD acts as a powerful decoy protein that out-performs soluble monomeric and dimeric ACE2 proteins and blocks both SARS-CoV-2 pseudovirus and SARS-CoV-2 virus infection with greatly enhanced efficacy. The ACE2 tetrameric protein complex promise to be important for development as decoy therapeutic proteins against COVID-19. In contrast to monoclonal antibodies, ACE2 decoy is unlikely to be affected by mutations in SARS-CoV-2 that are beginning to appear in variant forms. In addition, ACE2 multimeric proteins will be available as therapeutic proteins should new coronaviruses appear in the future because these are likely to interact with ACE2 receptor. |Angiotensin-Converting Enzyme 2/*chemistry/metabolism/*pharmacology[MESH] |Animals[MESH] |Antiviral Agents/chemistry/*metabolism[MESH] |COVID-19 Drug Treatment[MESH] |COVID-19/enzymology/*prevention & control/virology[MESH] |Cell Line[MESH] |Drug Design[MESH] |Haplorhini[MESH] |Humans[MESH] |Protein Binding[MESH] |Protein Engineering/*methods[MESH] |Protein Structural Elements[MESH] |SARS-CoV-2/*drug effects/isolation & purification/metabolism[MESH]A super-potent tetramerized ACE2 protein displays enhanced neutralizat(epmc).pdf DeepDyve Pubget Overpricing