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10.1097/MD.0000000000025719 http://scihub22266oqcxt.onion/10.1097/MD.0000000000025719 34011029!8137023!34011029     free     free     free Deprecated: Implicit conversion from float 235.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 235.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 235.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 235.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 235.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 235.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 269.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Medicine+(Baltimore) 2021 ; 100 (20): e25719 Nephropedia Template TP {{tp|p=34011029|t=2021. Corticosteroid therapy for COVID-19: A systematic review and meta-analysis of randomized controlled trials |pdf=|usr=}}{{34011029}} gab.com Text Corticosteroid therapy for COVID-19: A systematic review and meta-analysis of randomized controlled trials JO: Medicine (Baltimore) http://www.kidney.de/pget.php?&tw=1&pmid=34011029 #FOAvip BACKGROUND: Corticosteroid treatment is an effective and common therapeutic strategy for various inflammatory lung pathologies and may be an effective treatment for coronavirus disease 2019 (COVID-19). The purpose of this systematic review and meta-analysis of current literature was to investigate the clinical outcomes associated with corticosteroid treatment of COVID-19. METHODS: We systematically searched PubMed, medRxiv, Web of Science, and Scopus databases through March 10, 2021 to identify randomized controlled trials (RCTs) that evaluated the effects of corticosteroid therapies for COVID-19 treatment. Outcomes of interest were mortality, need for mechanical ventilation, serious adverse events (SAEs), and superinfection. RESULTS: A total of 7737 patients from 8 RCTs were included in the quantitative meta-analysis, of which 2795 (36.1%) patients received corticosteroids plus standard of care (SOC) while 4942 (63.9%) patients received placebo and/or SOC alone. The odds of mortality were significantly lower in patients that received corticosteroids as compared to SOC (odds ratio [OR] = 0.85 [95% CI: 0.76; 0.95], P = .003). Corticosteroid treatment reduced the odds of a need for mechanical ventilation as compared to SOC (OR = 0.76 [95% CI: 0.59; 0.97], P = .030). There was no significant difference between the corticosteroid and SOC groups with regards to SAEs and superinfections. CONCLUSION: Corticosteroid treatment can reduce the odds for mortality and the need for mechanical ventilation in severe COVID-19 patients. Twit Text FOAVip Corticosteroid therapy for COVID-19: A systematic review and meta-analysis of randomized controlled trials ????Medicine (Baltimore) http://www.kidney.de/pget.php?&tw=1&pmid=34011029 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=34011029 #FOAvip English Wikipedia <ref>{{Cite pmid|34011029}}</ref> Corticosteroid therapy for COVID-19: A systematic review and meta-analysis of randomized controlled trials #MMPMID34011029 Pulakurthi YS; Pederson JM; Saravu K; Gupta N; Balasubramanian P; Kamrowski S; Schmidt M; Vegivinti CTR; Dibas M; Reierson NL; Pisipati S; Joseph BA; Selvan PT; Dmytriw AA; Keesari PR; Sriram V; Chittajallu S; Brinjikji W; Katamreddy RR; Chibbar R; Davis AR; Malpe M; Mishra HK; Kallmes KM; Hassan AE; Evanson KW Medicine (Baltimore) 2021[May]; 100 (20): e25719 PMID34011029show ga BACKGROUND: Corticosteroid treatment is an effective and common therapeutic strategy for various inflammatory lung pathologies and may be an effective treatment for coronavirus disease 2019 (COVID-19). The purpose of this systematic review and meta-analysis of current literature was to investigate the clinical outcomes associated with corticosteroid treatment of COVID-19. METHODS: We systematically searched PubMed, medRxiv, Web of Science, and Scopus databases through March 10, 2021 to identify randomized controlled trials (RCTs) that evaluated the effects of corticosteroid therapies for COVID-19 treatment. Outcomes of interest were mortality, need for mechanical ventilation, serious adverse events (SAEs), and superinfection. RESULTS: A total of 7737 patients from 8 RCTs were included in the quantitative meta-analysis, of which 2795 (36.1%) patients received corticosteroids plus standard of care (SOC) while 4942 (63.9%) patients received placebo and/or SOC alone. The odds of mortality were significantly lower in patients that received corticosteroids as compared to SOC (odds ratio [OR] = 0.85 [95% CI: 0.76; 0.95], P = .003). Corticosteroid treatment reduced the odds of a need for mechanical ventilation as compared to SOC (OR = 0.76 [95% CI: 0.59; 0.97], P = .030). There was no significant difference between the corticosteroid and SOC groups with regards to SAEs and superinfections. CONCLUSION: Corticosteroid treatment can reduce the odds for mortality and the need for mechanical ventilation in severe COVID-19 patients. |*COVID-19 Drug Treatment[MESH] |Adrenal Cortex Hormones/*therapeutic use[MESH] |COVID-19/mortality[MESH] |Humans[MESH] |Odds Ratio[MESH] |Randomized Controlled Trials as Topic[MESH] |Respiration, Artificial/statistics & numerical data[MESH] |SARS-CoV-2[MESH]Corticosteroid therapy for COVID-19: A systematic review and meta-anal(epmc).pdf DeepDyve Pubget Overpricing