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10.1016/j.cell.2021.04.045 http://scihub22266oqcxt.onion/10.1016/j.cell.2021.04.045 34010620!8096189!34010620     free     free     free Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Cell 2021 ; 184 (11): 2927-2938.e11 Nephropedia Template TP {{tp|p=34010620|t=2021. High-resolution profiling of pathways of escape for SARS-CoV-2 spike-binding antibodies |pdf=|usr=}}{{34010620}} gab.com Text High-resolution profiling of pathways of escape for SARS-CoV-2 spike-binding antibodies JO: Cell http://www.kidney.de/pget.php?&tw=1&pmid=34010620 #FOAvip Defining long-term protective immunity to SARS-CoV-2 is one of the most pressing questions of our time and will require a detailed understanding of potential ways this virus can evolve to escape immune protection. Immune protection will most likely be mediated by antibodies that bind to the viral entry protein, spike (S). Here, we used Phage-DMS, an approach that comprehensively interrogates the effect of all possible mutations on binding to a protein of interest, to define the profile of antibody escape to the SARS-CoV-2 S protein using coronavirus disease 2019 (COVID-19) convalescent plasma. Antibody binding was common in two regions, the fusion peptide and the linker region upstream of the heptad repeat region 2. However, escape mutations were variable within these immunodominant regions. There was also individual variation in less commonly targeted epitopes. This study provides a granular view of potential antibody escape pathways and suggests there will be individual variation in antibody-mediated virus evolution. Twit Text FOAVip High-resolution profiling of pathways of escape for SARS-CoV-2 spike-binding antibodies ????Cell http://www.kidney.de/pget.php?&tw=1&pmid=34010620 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=34010620 #FOAvip English Wikipedia <ref>{{Cite pmid|34010620}}</ref> High-resolution profiling of pathways of escape for SARS-CoV-2 spike-binding antibodies #MMPMID34010620 Garrett ME; Galloway J; Chu HY; Itell HL; Stoddard CI; Wolf CR; Logue JK; McDonald D; Weight H; Matsen FA 4th; Overbaugh J Cell 2021[May]; 184 (11): 2927-2938.e11 PMID34010620show ga Defining long-term protective immunity to SARS-CoV-2 is one of the most pressing questions of our time and will require a detailed understanding of potential ways this virus can evolve to escape immune protection. Immune protection will most likely be mediated by antibodies that bind to the viral entry protein, spike (S). Here, we used Phage-DMS, an approach that comprehensively interrogates the effect of all possible mutations on binding to a protein of interest, to define the profile of antibody escape to the SARS-CoV-2 S protein using coronavirus disease 2019 (COVID-19) convalescent plasma. Antibody binding was common in two regions, the fusion peptide and the linker region upstream of the heptad repeat region 2. However, escape mutations were variable within these immunodominant regions. There was also individual variation in less commonly targeted epitopes. This study provides a granular view of potential antibody escape pathways and suggests there will be individual variation in antibody-mediated virus evolution. |Algorithms[MESH] |Antibodies, Neutralizing/*immunology[MESH] |Antibodies, Viral/*immunology[MESH] |COVID-19 Serotherapy[MESH] |COVID-19/*immunology/therapy/virology[MESH] |Cell Line[MESH] |Epitopes/*immunology[MESH] |Gene Library[MESH] |Humans[MESH] |Immunization, Passive[MESH] |Mutation[MESH] |Protein Domains[MESH] |SARS-CoV-2/genetics/*immunology[MESH] |Software[MESH]High-resolution profiling of pathways of escape for SARS-CoV-2 spike-b(epmc).pdf DeepDyve Pubget Overpricing