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10.1091/mbc.E21-02-0074 http://scihub22266oqcxt.onion/10.1091/mbc.E21-02-0074 34010015!8351553!34010015     free     free     free Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Mol+Biol+Cell 2021 ; 32 (14): 1273-1282 Nephropedia Template TP {{tp|p=34010015|t=2021. Peroxisomes exhibit compromised structure and matrix protein content in SARS-CoV-2-infected cells |pdf=|usr=}}{{34010015}} gab.com Text Peroxisomes exhibit compromised structure and matrix protein content in SARS-CoV-2-infected cells JO: Mol Biol Cell http://www.kidney.de/pget.php?&tw=1&pmid=34010015 #FOAvip Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is a novel coronavirus that has triggered global health and economic crises. Here we report the effects of SARS-CoV-2 infection on peroxisomes of human cell lines Huh-7 and SK-N-SH. Peroxisomes undergo dramatic changes in morphology in SARS-CoV-2-infected cells. Rearrangement of peroxisomal membranes is followed by redistribution of peroxisomal matrix proteins to the cytosol, resulting in a dramatic decrease in the number of mature peroxisomes. The SARS-CoV-2 ORF14 protein was shown to interact physically with human PEX14, a peroxisomal membrane protein required for matrix protein import and peroxisome biogenesis. Given the important roles of peroxisomes in innate immunity, SARS-CoV-2 may directly target peroxisomes, resulting in loss of peroxisome structural integrity, matrix protein content and ability to function in antiviral signaling. Twit Text FOAVip Peroxisomes exhibit compromised structure and matrix protein content in SARS-CoV-2-infected cells ????Mol Biol Cell http://www.kidney.de/pget.php?&tw=1&pmid=34010015 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=34010015 #FOAvip English Wikipedia <ref>{{Cite pmid|34010015}}</ref> Peroxisomes exhibit compromised structure and matrix protein content in SARS-CoV-2-infected cells #MMPMID34010015 Knoblach B; Ishida R; Hobman TC; Rachubinski RA Mol Biol Cell 2021[Jul]; 32 (14): 1273-1282 PMID34010015show ga Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is a novel coronavirus that has triggered global health and economic crises. Here we report the effects of SARS-CoV-2 infection on peroxisomes of human cell lines Huh-7 and SK-N-SH. Peroxisomes undergo dramatic changes in morphology in SARS-CoV-2-infected cells. Rearrangement of peroxisomal membranes is followed by redistribution of peroxisomal matrix proteins to the cytosol, resulting in a dramatic decrease in the number of mature peroxisomes. The SARS-CoV-2 ORF14 protein was shown to interact physically with human PEX14, a peroxisomal membrane protein required for matrix protein import and peroxisome biogenesis. Given the important roles of peroxisomes in innate immunity, SARS-CoV-2 may directly target peroxisomes, resulting in loss of peroxisome structural integrity, matrix protein content and ability to function in antiviral signaling. |Animals[MESH] |Cell Line[MESH] |Cell Membrane/pathology[MESH] |Chlorocebus aethiops[MESH] |Coronavirus Nucleocapsid Proteins/metabolism[MESH] |Extracellular Matrix Proteins/metabolism[MESH] |Humans[MESH] |Membrane Proteins/metabolism[MESH] |Peroxisomes/metabolism/pathology/*virology[MESH] |Phosphoproteins/metabolism[MESH] |Repressor Proteins/metabolism[MESH] |SARS-CoV-2/metabolism[MESH]Peroxisomes exhibit compromised structure and matrix protein content i(epmc).pdf DeepDyve Pubget Overpricing