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10.1007/s00408-021-00443-9 http://scihub22266oqcxt.onion/10.1007/s00408-021-00443-9 34009429!8132740!34009429     free     free     free Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Lung 2021 ; 199 (3): 255-261 Nephropedia Template TP {{tp|p=34009429|t=2021. Noninvasive Measurement of Pulmonary Function in Experimental Mouse Models of Airway Disease |pdf=|usr=}}{{34009429}} gab.com Text Noninvasive Measurement of Pulmonary Function in Experimental Mouse Models of Airway Disease JO: Lung http://www.kidney.de/pget.php?&tw=1&pmid=34009429 #FOAvip Mouse models have become an indispensable tool in translational research of human airway disease and have provided much of our understanding of the pathogenesis of airway disease such as asthma. In these models the ability to assess pulmonary function and particularly airway responsiveness is critically important. Existing methods for testing pulmonary function in mice in vivo include noninvasive and invasive technologies. Noninvasive head-out body plethysmography is a well-established and widely accepted technique which has been proven as a reliable method to measure lung function on repeated occasions in intact, conscious mice. We have performed several validation studies in allergic mice to compare the parameter midexpiratory flow (EF(50)) as a noninvasive marker of airflow limitation with invasively measured gold standard parameters of lung mechanics. The results of these studies showed a good agreement of EF(50) with the invasive assessment of lung resistance and dynamic compliance with a somewhat lower sensitivity of EF(50). The measurement of EF(50) together with basic respiratory parameters is particularly appropriate for simple and repeatable screening of pulmonary function in large numbers of mice or if noninvasive measurement without use of anesthesia is required. Beyond known applications, head-out body plethysmography also provides a much-needed high-throughput screening tool to gain insights into the impact and kinetics of respiratory infections such as SARS-COV-2 on lung physiology in laboratory mice. Twit Text FOAVip Noninvasive Measurement of Pulmonary Function in Experimental Mouse Models of Airway Disease ????Lung http://www.kidney.de/pget.php?&tw=1&pmid=34009429 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=34009429 #FOAvip English Wikipedia <ref>{{Cite pmid|34009429}}</ref> Noninvasive Measurement of Pulmonary Function in Experimental Mouse Models of Airway Disease #MMPMID34009429 Glaab T; Braun A Lung 2021[Jun]; 199 (3): 255-261 PMID34009429show ga Mouse models have become an indispensable tool in translational research of human airway disease and have provided much of our understanding of the pathogenesis of airway disease such as asthma. In these models the ability to assess pulmonary function and particularly airway responsiveness is critically important. Existing methods for testing pulmonary function in mice in vivo include noninvasive and invasive technologies. Noninvasive head-out body plethysmography is a well-established and widely accepted technique which has been proven as a reliable method to measure lung function on repeated occasions in intact, conscious mice. We have performed several validation studies in allergic mice to compare the parameter midexpiratory flow (EF(50)) as a noninvasive marker of airflow limitation with invasively measured gold standard parameters of lung mechanics. The results of these studies showed a good agreement of EF(50) with the invasive assessment of lung resistance and dynamic compliance with a somewhat lower sensitivity of EF(50). The measurement of EF(50) together with basic respiratory parameters is particularly appropriate for simple and repeatable screening of pulmonary function in large numbers of mice or if noninvasive measurement without use of anesthesia is required. Beyond known applications, head-out body plethysmography also provides a much-needed high-throughput screening tool to gain insights into the impact and kinetics of respiratory infections such as SARS-COV-2 on lung physiology in laboratory mice. |Airway Resistance[MESH] |Animals[MESH] |COVID-19/*physiopathology[MESH] |Disease Models, Animal[MESH] |Lung/physiopathology[MESH] |Mice[MESH] |Plethysmography, Whole Body/*methods[MESH] |Respiratory Function Tests/*methods[MESH] |Respiratory Mechanics[MESH]Noninvasive Measurement of Pulmonary Function in Experimental Mouse Mo(epmc).pdf DeepDyve Pubget Overpricing