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10.1186/s12879-021-06168-7

http://scihub22266oqcxt.onion/10.1186/s12879-021-06168-7
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suck abstract from ncbi


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pmid34006228      BMC+Infect+Dis 2021 ; 21 (1): 450
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  • Lack of association between vitamin D insufficiency and clinical outcomes of patients with COVID-19 infection #MMPMID34006228
  • Davoudi A; Najafi N; Aarabi M; Tayebi A; Nikaeen R; Izadyar H; Salar Z; Delavarian L; Vaseghi N; Daftarian Z; Ahangarkani F
  • BMC Infect Dis 2021[May]; 21 (1): 450 PMID34006228show ga
  • BACKGROUND: A protective effect of vitamin D against COVID-19 infection is under investigation. We aimed to analyze the effect of vitamin D sufficiency on the clinical outcomes of patients infected with COVID-19. METHODS: In this cross-sectional study we analyzed the vitamin D levels of COVID-19 patients who were admitted to Razi Hospital (an infectious disease referral center in Mazandaran province in northern Iran) from February to March 2020. Overall, a cutoff point of 30 ng/mL was used for the definition of vitamin D sufficiency. RESULTS: One hundred fifty-three patients were analyzed in this study who had laboratory documentation of a 25(OH) D level at the time of hospitalization. The vitamin D levels of the patients were 27.19 +/- 20.17 ng/mL. In total, 62.7% (n = 96) of the patients had a 25(OH) D level of less than 30 ng/mL and 37.25% (n = 57) had a 25(OH) D level of more than 30 ng/mL. In total, 49% (n = 75) of the patients suffered from at least one underlying disease. The univariate and multivariable regression showed that vitamin D sufficiency was not associated with a statistically significant lower risk of adverse clinical outcomes of COVID-19 such as duration of hospitalization and severity of infection (P > 0.05). CONCLUSIONS: Sufficient vitamin D levels were not found to be protective against adverse clinical outcomes in patients infected with COVID-19. Chronic disorders in COVID-19 patients were found to have greater relevance than vitamin D levels in determining the adverse outcomes of the infection. Further studies are needed to determine the role of vitamin D level in predicting the outcomes of COVID-19 infection.
  • |*Length of Stay[MESH]
  • |*Severity of Illness Index[MESH]
  • |Adult[MESH]
  • |Aged[MESH]
  • |COVID-19 Nucleic Acid Testing[MESH]
  • |COVID-19/*complications/epidemiology/virology[MESH]
  • |Calcifediol/blood/*deficiency[MESH]
  • |Cross-Sectional Studies[MESH]
  • |Female[MESH]
  • |Hospitalization[MESH]
  • |Hospitals[MESH]
  • |Humans[MESH]
  • |Iran/epidemiology[MESH]
  • |Male[MESH]
  • |Middle Aged[MESH]
  • |Retrospective Studies[MESH]
  • |SARS-CoV-2/*genetics[MESH]


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