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10.1016/j.coi.2021.04.005 http://scihub22266oqcxt.onion/10.1016/j.coi.2021.04.005 34004375!8123722!34004375     free     free     free Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Curr+Opin+Immunol 2021 ; 72 (ä): 126-134 Nephropedia Template TP {{tp|p=34004375|t=2021. Membrane cofactor protein (MCP; CD46): deficiency states and pathogen connections |pdf=|usr=}}{{34004375}} gab.com Text Membrane cofactor protein (MCP; CD46): deficiency states and pathogen connections JO: Curr Opin Immunol http://www.kidney.de/pget.php?&tw=1&pmid=34004375 #FOAvip Membrane cofactor protein (MCP; CD46), a ubiquitously expressed complement regulatory protein, serves as a cofactor for serine protease factor I to cleave and inactivate C3b and C4b deposited on host cells. However, CD46 also plays roles in human reproduction, autophagy, modulating T cell activation and effector functions and is a member of the newly identified intracellular complement system (complosome). CD46 also is a receptor for 11 pathogens ('pathogen magnet'). While CD46 deficiencies contribute to inflammatory disorders, its overexpression in cancers and role as a receptor for some adenoviruses has led to its targeting by oncolytic agents and adenoviral-based therapeutic vectors, including coronavirus disease of 2019 (COVID-19) vaccines. This review focuses on recent advances in identifying disease-causing CD46 variants and its pathogen connections. Twit Text FOAVip Membrane cofactor protein (MCP; CD46): deficiency states and pathogen connections ????Curr Opin Immunol http://www.kidney.de/pget.php?&tw=1&pmid=34004375 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=34004375 #FOAvip English Wikipedia <ref>{{Cite pmid|34004375}}</ref> Membrane cofactor protein (MCP; CD46): deficiency states and pathogen connections #MMPMID34004375 Liszewski MK; Atkinson JP Curr Opin Immunol 2021[Oct]; 72 (ä): 126-134 PMID34004375show ga Membrane cofactor protein (MCP; CD46), a ubiquitously expressed complement regulatory protein, serves as a cofactor for serine protease factor I to cleave and inactivate C3b and C4b deposited on host cells. However, CD46 also plays roles in human reproduction, autophagy, modulating T cell activation and effector functions and is a member of the newly identified intracellular complement system (complosome). CD46 also is a receptor for 11 pathogens ('pathogen magnet'). While CD46 deficiencies contribute to inflammatory disorders, its overexpression in cancers and role as a receptor for some adenoviruses has led to its targeting by oncolytic agents and adenoviral-based therapeutic vectors, including coronavirus disease of 2019 (COVID-19) vaccines. This review focuses on recent advances in identifying disease-causing CD46 variants and its pathogen connections. |Animals[MESH] |Autophagy[MESH] |COVID-19 Vaccines/*immunology[MESH] |COVID-19/*immunology[MESH] |Complement Activation[MESH] |Host-Pathogen Interactions[MESH] |Humans[MESH] |Lymphocyte Activation[MESH] |Membrane Cofactor Protein/genetics/*metabolism[MESH] |Oncolytic Virotherapy[MESH] |Polymorphism, Genetic[MESH] |Reproduction[MESH] |SARS-CoV-2/*physiology[MESH]Membrane cofactor protein (MCP; CD46): deficiency states and pathogen (epmc).pdf DeepDyve Pubget Overpricing