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10.1016/j.celrep.2021.109179

http://scihub22266oqcxt.onion/10.1016/j.celrep.2021.109179
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suck abstract from ncbi


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pmid34004174      Cell+Rep 2021 ; 35 (8): 109179
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  • Mapping the SARS-CoV-2 spike glycoprotein-derived peptidome presented by HLA class II on dendritic cells #MMPMID34004174
  • Parker R; Partridge T; Wormald C; Kawahara R; Stalls V; Aggelakopoulou M; Parker J; Powell Doherty R; Ariosa Morejon Y; Lee E; Saunders K; Haynes BF; Acharya P; Thaysen-Andersen M; Borrow P; Ternette N
  • Cell Rep 2021[May]; 35 (8): 109179 PMID34004174show ga
  • Understanding and eliciting protective immune responses to severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is an urgent priority. To facilitate these objectives, we profile the repertoire of human leukocyte antigen class II (HLA-II)-bound peptides presented by HLA-DR diverse monocyte-derived dendritic cells pulsed with SARS-CoV-2 spike (S) protein. We identify 209 unique HLA-II-bound peptide sequences, many forming nested sets, which map to sites throughout S including glycosylated regions. Comparison of the glycosylation profile of the S protein to that of the HLA-II-bound S peptides reveals substantial trimming of glycan residues on the latter, likely induced during antigen processing. Our data also highlight the receptor-binding motif in S1 as a HLA-DR-binding peptide-rich region and identify S2-derived peptides with potential for targeting by cross-protective vaccine-elicited responses. Results from this study will aid analysis of CD4(+) T cell responses in infected individuals and vaccine recipients and have application in next-generation vaccine design.
  • |Amino Acid Sequence[MESH]
  • |Antigen Presentation[MESH]
  • |COVID-19/*immunology/virology[MESH]
  • |Dendritic Cells/*immunology[MESH]
  • |Epitope Mapping[MESH]
  • |Epitopes, T-Lymphocyte/immunology[MESH]
  • |Glycosylation[MESH]
  • |Histocompatibility Antigens Class II/*immunology[MESH]
  • |Humans[MESH]
  • |Peptides/*immunology[MESH]
  • |Protein Binding[MESH]
  • |Protein Interaction Domains and Motifs[MESH]
  • |SARS-CoV-2/immunology[MESH]
  • |Spike Glycoprotein, Coronavirus/*immunology[MESH]


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