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10.1172/JCI148517 http://scihub22266oqcxt.onion/10.1172/JCI148517 34003804!8245175!34003804     free     free     free Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       J+Clin+Invest 2021 ; 131 (13): ä Nephropedia Template TP {{tp|p=34003804|t=2021. Nasal ciliated cells are primary targets for SARS-CoV-2 replication in the early stage of COVID-19 |pdf=|usr=}}{{34003804}} gab.com Text Nasal ciliated cells are primary targets for SARS-CoV-2 replication in the early stage of COVID-19 JO: J Clin Invest http://www.kidney.de/pget.php?&tw=1&pmid=34003804 #FOAvip The upper respiratory tract is compromised in the early period of COVID-19, but SARS-CoV-2 tropism at the cellular level is not fully defined. Unlike recent single-cell RNA-Seq analyses indicating uniformly low mRNA expression of SARS-CoV-2 entry-related host molecules in all nasal epithelial cells, we show that the protein levels are relatively high and that their localizations are restricted to the apical side of multiciliated epithelial cells. In addition, we provide evidence in patients with COVID-19 that SARS-CoV-2 is massively detected and replicated within the multiciliated cells. We observed these findings during the early stage of COVID-19, when infected ciliated cells were rapidly replaced by differentiating precursor cells. Moreover, our analyses revealed that SARS-CoV-2 cellular tropism was restricted to the nasal ciliated versus oral squamous epithelium. These results imply that targeting ciliated cells of the nasal epithelium during the early stage of COVID-19 could be an ideal strategy to prevent SARS-CoV-2 propagation. Twit Text FOAVip Nasal ciliated cells are primary targets for SARS-CoV-2 replication in the early stage of COVID-19 ????J Clin Invest http://www.kidney.de/pget.php?&tw=1&pmid=34003804 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=34003804 #FOAvip English Wikipedia <ref>{{Cite pmid|34003804}}</ref> Nasal ciliated cells are primary targets for SARS-CoV-2 replication in the early stage of COVID-19 #MMPMID34003804 Ahn JH; Kim J; Hong SP; Choi SY; Yang MJ; Ju YS; Kim YT; Kim HM; Rahman MDT; Chung MK; Hong SD; Bae H; Lee CS; Koh GY J Clin Invest 2021[Jul]; 131 (13): ä PMID34003804show ga The upper respiratory tract is compromised in the early period of COVID-19, but SARS-CoV-2 tropism at the cellular level is not fully defined. Unlike recent single-cell RNA-Seq analyses indicating uniformly low mRNA expression of SARS-CoV-2 entry-related host molecules in all nasal epithelial cells, we show that the protein levels are relatively high and that their localizations are restricted to the apical side of multiciliated epithelial cells. In addition, we provide evidence in patients with COVID-19 that SARS-CoV-2 is massively detected and replicated within the multiciliated cells. We observed these findings during the early stage of COVID-19, when infected ciliated cells were rapidly replaced by differentiating precursor cells. Moreover, our analyses revealed that SARS-CoV-2 cellular tropism was restricted to the nasal ciliated versus oral squamous epithelium. These results imply that targeting ciliated cells of the nasal epithelium during the early stage of COVID-19 could be an ideal strategy to prevent SARS-CoV-2 propagation. |*Host Microbial Interactions/genetics/physiology[MESH] |*SARS-CoV-2/genetics/pathogenicity/physiology[MESH] |Angiotensin-Converting Enzyme 2/genetics/metabolism[MESH] |Animals[MESH] |COVID-19/pathology/physiopathology/*virology[MESH] |Cell Differentiation[MESH] |Cilia/pathology/physiology/virology[MESH] |Furin/genetics/metabolism[MESH] |Humans[MESH] |Macaca[MESH] |Models, Biological[MESH] |Nasal Mucosa/pathology/physiopathology/*virology[MESH] |Pandemics[MESH] |RNA, Messenger/genetics/metabolism[MESH] |RNA-Seq[MESH] |Serine Endopeptidases/genetics/metabolism[MESH] |Stem Cells/pathology/virology[MESH] |Virus Internalization[MESH]Nasal ciliated cells are primary targets for SARS-CoV-2 replication in(epmc).pdf DeepDyve Pubget Overpricing