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10.1080/00365513.2021.1926536

http://scihub22266oqcxt.onion/10.1080/00365513.2021.1926536
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34003706!8146290!34003706
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suck abstract from ncbi

pmid34003706      Scand+J+Clin+Lab+Invest 2021 ; 81 (4): 272-275
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  • Serum ACE activity and plasma ACE concentration in patients with SARS-CoV-2 infection #MMPMID34003706
  • Henry BM; Benoit JL; Rose J; de Oliveira MHS; Lippi G; Benoit SW
  • Scand J Clin Lab Invest 2021[Jul]; 81 (4): 272-275 PMID34003706show ga
  • Significant controversy has arisen over the role of the renin-angiotensin-aldosterone system (RAAS) in COVID-19 pathophysiology. In this prospective, observational study, we evaluated plasma angiotensin converting enzyme (ACE) concentration and serum ACE activity in 52 adults with laboratory-confirmed SARS-CoV-2 infection and 27 non-COVID-19 sick controls. No significant differences were observed in ACE activity in COVID-19 patients versus non-COVID-19 sick controls (41.1 [interquartile range (IQR): 23.0-55.2] vs. 42.9 [IQR 13.6-74.2] U/L, p = .649, respectively). Similarly, no differences were observed in ACE concentration in COVID-19 patients versus non-COVID-19 sick controls (108.4 [IQR: 95.8-142.2] vs. 133.8 [IQR: 100.2-173.7] mug/L, p = .059, respectively). Neither ACE activity (p = .751), nor ACE concentration (p = .283) was associated with COVID-19 severity. Moreover, neither ACE activity, nor ACE concentration was correlated with any inflammatory biomarkers.
  • |*COVID-19[MESH]
  • |*SARS-CoV-2[MESH]
  • |Adult[MESH]
  • |Angiotensin-Converting Enzyme Inhibitors[MESH]
  • |Humans[MESH]
  • |Peptidyl-Dipeptidase A[MESH]


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