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10.1080/22221751.2021.1931465 http://scihub22266oqcxt.onion/10.1080/22221751.2021.1931465 34003073!8186430!34003073     free     free     free Warning: file_get_contents(https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&id=34003073&cmd=llinks): Failed to open stream: HTTP request failed! HTTP/1.1 429 Too Many Requests in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 215 Deprecated: Implicit conversion from float 217.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 217.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 217.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 217.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Emerg+Microbes+Infect 2021 ; 10 (1): 1016-1023 Nephropedia Template TP {{tp|p=34003073|t=2021. Mining of linear B cell epitopes of SARS-CoV-2 ORF8 protein from COVID-19 patients |pdf=|usr=}}{{34003073}} gab.com Text Mining of linear B cell epitopes of SARS-CoV-2 ORF8 protein from COVID-19 patients JO: Emerg Microbes Infect http://www.kidney.de/pget.php?&tw=1&pmid=34003073 #FOAvip Given the on-going SARS-CoV-2 pandemic, identification of immunogenic targets against the viral protein will provide crucial advances towards the development of sensitive diagnostic tools and vaccination strategies. Our previous study has found that ORF8 protein of SARS-CoV-2 is highly immunogenic and shows high sensitivity in identifying COVID-19 disease. In this study, by employing overlapping linear peptides, we characterized the IgG immunodominant regions on SARS-CoV-2 ORF8 protein that are seropositive in the sera from SARS-CoV-2-infected patients. The major immunogenic epitopes are localized at (1) N-termini alpha helix, (2) the resides spanning beta 2 and 3 sheets, and (3) the loop between beta 4 and 5 sheets. Additionally, hamster model infected by SARS-CoV-2 further validates the seropositivity of the linear epitopes in vivo, demonstrating a potential application of the linear peptide-based immunization strategy. Taken together, identification and validation of these B-cell linear epitopes will provide insights into the design of serological diagnostics and peptide-based vaccination approach against this pandemic virus of high priority. Twit Text FOAVip Mining of linear B cell epitopes of SARS-CoV-2 ORF8 protein from COVID-19 patients ????Emerg Microbes Infect http://www.kidney.de/pget.php?&tw=1&pmid=34003073 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=34003073 #FOAvip English Wikipedia <ref>{{Cite pmid|34003073}}</ref> Mining of linear B cell epitopes of SARS-CoV-2 ORF8 protein from COVID-19 patients #MMPMID34003073 Wang X; Lam JY; Chen L; Au SW; To KKW; Yuen KY; Kok KH Emerg Microbes Infect 2021[Dec]; 10 (1): 1016-1023 PMID34003073show ga Given the on-going SARS-CoV-2 pandemic, identification of immunogenic targets against the viral protein will provide crucial advances towards the development of sensitive diagnostic tools and vaccination strategies. Our previous study has found that ORF8 protein of SARS-CoV-2 is highly immunogenic and shows high sensitivity in identifying COVID-19 disease. In this study, by employing overlapping linear peptides, we characterized the IgG immunodominant regions on SARS-CoV-2 ORF8 protein that are seropositive in the sera from SARS-CoV-2-infected patients. The major immunogenic epitopes are localized at (1) N-termini alpha helix, (2) the resides spanning beta 2 and 3 sheets, and (3) the loop between beta 4 and 5 sheets. Additionally, hamster model infected by SARS-CoV-2 further validates the seropositivity of the linear epitopes in vivo, demonstrating a potential application of the linear peptide-based immunization strategy. Taken together, identification and validation of these B-cell linear epitopes will provide insights into the design of serological diagnostics and peptide-based vaccination approach against this pandemic virus of high priority. |*Epitopes, B-Lymphocyte[MESH] |Animals[MESH] |Antibodies, Viral[MESH] |COVID-19/*immunology[MESH] |Cricetinae[MESH] |Humans[MESH] |Immunodominant Epitopes[MESH] |Mesocricetus[MESH] |Models, Molecular[MESH] |Protein Conformation[MESH] |SARS-CoV-2/*immunology[MESH]Mining of linear B cell epitopes of SARS-CoV-2 ORF8 protein from COVID(epmc).pdf DeepDyve Pubget Overpricing