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10.1038/s41467-021-23005-2 http://scihub22266oqcxt.onion/10.1038/s41467-021-23005-2 34001887!8128914!34001887     free     free     free Deprecated: Implicit conversion from float 235.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 235.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 235.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 235.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 235.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 235.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 235.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 269.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 269.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 269.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Nat+Commun 2021 ; 12 (1): 2885 Nephropedia Template TP {{tp|p=34001887|t=2021. TRPM7 kinase-mediated immunomodulation in macrophage plays a central role in magnesium ion-induced bone regeneration |pdf=|usr=}}{{34001887}} gab.com Text TRPM7 kinase-mediated immunomodulation in macrophage plays a central role in magnesium ion-induced bone regeneration JO: Nat Commun http://www.kidney.de/pget.php?&tw=1&pmid=34001887 #FOAvip Despite the widespread observations on the osteogenic effects of magnesium ion (Mg(2+)), the diverse roles of Mg(2+) during bone healing have not been systematically dissected. Here, we reveal a previously unknown, biphasic mode of action of Mg(2+) in bone repair. During the early inflammation phase, Mg(2+) contributes to an upregulated expression of transient receptor potential cation channel member 7 (TRPM7), and a TRPM7-dependent influx of Mg(2+) in the monocyte-macrophage lineage, resulting in the cleavage and nuclear accumulation of TRPM7-cleaved kinase fragments (M7CKs). This then triggers the phosphorylation of Histone H3 at serine 10, in a TRPM7-dependent manner at the promoters of inflammatory cytokines, leading to the formation of a pro-osteogenic immune microenvironment. In the later remodeling phase, however, the continued exposure of Mg(2+) not only lead to the over-activation of NF-kappaB signaling in macrophages and increased number of osteoclastic-like cells but also decelerates bone maturation through the suppression of hydroxyapatite precipitation. Thus, the negative effects of Mg(2+) on osteogenesis can override the initial pro-osteogenic benefits of Mg(2+). Taken together, this study establishes a paradigm shift in the understanding of the diverse and multifaceted roles of Mg(2+) in bone healing. Twit Text FOAVip TRPM7 kinase-mediated immunomodulation in macrophage plays a central role in magnesium ion-induced bone regeneration ????Nat Commun http://www.kidney.de/pget.php?&tw=1&pmid=34001887 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=34001887 #FOAvip English Wikipedia <ref>{{Cite pmid|34001887}}</ref> TRPM7 kinase-mediated immunomodulation in macrophage plays a central role in magnesium ion-induced bone regeneration #MMPMID34001887 Qiao W; Wong KHM; Shen J; Wang W; Wu J; Li J; Lin Z; Chen Z; Matinlinna JP; Zheng Y; Wu S; Liu X; Lai KP; Chen Z; Lam YW; Cheung KMC; Yeung KWK Nat Commun 2021[May]; 12 (1): 2885 PMID34001887show ga Despite the widespread observations on the osteogenic effects of magnesium ion (Mg(2+)), the diverse roles of Mg(2+) during bone healing have not been systematically dissected. Here, we reveal a previously unknown, biphasic mode of action of Mg(2+) in bone repair. During the early inflammation phase, Mg(2+) contributes to an upregulated expression of transient receptor potential cation channel member 7 (TRPM7), and a TRPM7-dependent influx of Mg(2+) in the monocyte-macrophage lineage, resulting in the cleavage and nuclear accumulation of TRPM7-cleaved kinase fragments (M7CKs). This then triggers the phosphorylation of Histone H3 at serine 10, in a TRPM7-dependent manner at the promoters of inflammatory cytokines, leading to the formation of a pro-osteogenic immune microenvironment. In the later remodeling phase, however, the continued exposure of Mg(2+) not only lead to the over-activation of NF-kappaB signaling in macrophages and increased number of osteoclastic-like cells but also decelerates bone maturation through the suppression of hydroxyapatite precipitation. Thus, the negative effects of Mg(2+) on osteogenesis can override the initial pro-osteogenic benefits of Mg(2+). Taken together, this study establishes a paradigm shift in the understanding of the diverse and multifaceted roles of Mg(2+) in bone healing. |Animals[MESH] |Bone Regeneration/*drug effects[MESH] |Cell Differentiation/drug effects[MESH] |Cells, Cultured[MESH] |Cytokines/immunology/metabolism[MESH] |Femur/*drug effects/metabolism/pathology[MESH] |Gene Expression/drug effects[MESH] |Humans[MESH] |Immunomodulation/*drug effects[MESH] |Inflammation/metabolism[MESH] |Macrophages/cytology/immunology/*metabolism[MESH] |Magnesium/administration & dosage/metabolism/*pharmacology[MESH] |Osteoclasts/cytology/drug effects[MESH] |Osteogenesis/drug effects/genetics[MESH] |Protein Serine-Threonine Kinases/genetics/*metabolism[MESH] |Rats[MESH] |Rats, Sprague-Dawley[MESH] |THP-1 Cells[MESH]TRPM7 kinase-mediated immunomodulation in macrophage plays a central r(epmc).pdf DeepDyve Pubget Overpricing