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10.1186/s13014-021-01817-2

http://scihub22266oqcxt.onion/10.1186/s13014-021-01817-2
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suck abstract from ncbi


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pmid34001182      Radiat+Oncol 2021 ; 16 (1): 91
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  • DE-MR simulation imaging for prone radiotherapy after breast-conserving surgery: assessing its application in lumpectomy cavity delineation based on deformable image registration #MMPMID34001182
  • Zhao C; Li J; Wang W; Gong G; Xu L; Zhang Y; Li F; Shao Q; Wang J; Liu X; Xu M
  • Radiat Oncol 2021[May]; 16 (1): 91 PMID34001182show ga
  • BACKGROUND: The application of delayed-enhancement magnetic resonance (DE-MR) simulation imaging in lumpectomy cavity (LC) delineation for prone radiotherapy in patients with an invisible seroma or a low seroma clarity score (SCS) after breast-conserving surgery (BCS) based on deformable image registration (DIR) was assessed. METHODS: Twenty-six patients who were suitable for radiotherapy in prone positions after BCS were enrolled, and both computed tomography (CT) and DE-MR simulation scans were acquired. The LC delineated based on titanium surgical clips on CT images was denoted as LC(CT). The LC delineated based on the signal of cavity boundaries on fat-suppressed T2-weighted imaging (T2WI) and multiphase delayed-enhancement T1-weighted imaging (DE-T1WI), which was performed at 2 min, 5 min and 10 min postinjection, were denoted as LC(T2), LC(2T1), LC(5T1) and LC(10T1), respectively. Afterwards, DIR was performed to compare the volumes and locations of the LCs with MIM software. The generalized conformity index (CIgen) of inter (intra) observer (Inter-CIgen and Intra-CIgen) was also used to explore the inter(intra) observer variation for LC delineation on each image modality. RESULTS: LC(CT)-LC(10T1) provided the best conformal index (CI) and degree of inclusion (DI), increasing by 2.08% and 4.48% compared to LC(CT)-LC(T2), 11.36% and 2.94% for LC(CT)-LC(2T1), and 8.89% and 7.69% for LC(5T1)-LC(CT), respectively. The center of mass (COM) of LC(CT)-LC(10T1) decreased by 17.86%, 6.12% and 13.21% compared with that of LC(CT)-LC(T2), LC(CT)-LC(2T1) and LC(CT)-LC(5T1), respectively. The agreement of LC delineation was strongest for 10th min DE-TIWI (coefficient of variation, COV = 2.30%, Inter-CIgen = 87.06%, Intra-CIgen = 92.64%). CONCLUSION: For patients with a low SCS (SCS
  • |*Mastectomy, Segmental[MESH]
  • |*Prone Position[MESH]
  • |*Radiotherapy, Adjuvant[MESH]
  • |Adult[MESH]
  • |Breast Neoplasms/diagnostic imaging/*radiotherapy/surgery[MESH]
  • |Breast/*diagnostic imaging[MESH]
  • |Female[MESH]
  • |Fiducial Markers[MESH]
  • |Humans[MESH]
  • |Magnetic Resonance Imaging/*methods[MESH]
  • |Middle Aged[MESH]
  • |Postoperative Complications/*diagnostic imaging/etiology[MESH]
  • |Radiotherapy Planning, Computer-Assisted/*methods[MESH]
  • |Seroma/*diagnostic imaging/etiology[MESH]
  • |Titanium[MESH]


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