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10.1016/j.jneuroim.2021.577599

http://scihub22266oqcxt.onion/10.1016/j.jneuroim.2021.577599
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34000472!8095041!34000472
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suck abstract from ncbi


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pmid34000472      J+Neuroimmunol 2021 ; 356 (ä): 577599
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  • Safety and efficacy of COVID-19 vaccines in multiple sclerosis patients #MMPMID34000472
  • Kelly H; Sokola B; Abboud H
  • J Neuroimmunol 2021[Jul]; 356 (ä): 577599 PMID34000472show ga
  • COVID-19 vaccination is recommended for multiple sclerosis patients. Disease-modifying therapies can influence the safety and efficacy of COVID-19 vaccines. RNA, DNA, protein, and inactivated vaccines are likely safe for multiple sclerosis patients. A few incidences of central demyelination were reported with viral vector vaccines, but their benefits likely outweigh their risks if alternatives are unavailable. Live-attenuated vaccines should be avoided whenever possible in treated patients. Interferon-beta, glatiramer acetate, teriflunomide, fumarates, and natalizumab are not expected to impact vaccine efficacy, while cell-depleting agents (ocrelizumab, rituximab, ofatumumab, alemtuzumab, and cladribine) and sphingosine-1-phosphate modulators will likely attenuate vaccine responses. Coordinating vaccine timing with dosing regimens for some therapies may optimize vaccine efficacy.
  • |Antirheumatic Agents/therapeutic use[MESH]
  • |COVID-19 Vaccines/*therapeutic use[MESH]
  • |COVID-19/complications/*prevention & control[MESH]
  • |Humans[MESH]
  • |Immunocompromised Host/*drug effects[MESH]
  • |Multiple Sclerosis/complications/drug therapy/*immunology[MESH]


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