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10.1016/j.peptides.2021.170570

http://scihub22266oqcxt.onion/10.1016/j.peptides.2021.170570
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34000327!8120785!34000327
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suck abstract from ncbi


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pmid34000327      Peptides 2021 ; 142 (ä): 170570
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  • Review of antiviral peptides for use against zoonotic and selected non-zoonotic viruses #MMPMID34000327
  • Hollmann A; Cardoso NP; Espeche JC; Maffia PC
  • Peptides 2021[Aug]; 142 (ä): 170570 PMID34000327show ga
  • Viruses remain one of the leading causes of animal and human disease. Some animal viral infections spread sporadically to human populations, posing a serious health risk. Particularly the emerging viral zoonotic diseases such as the novel, zoonotic coronavirus represent an actual challenge for the scientific and medical community. Besides human health risks, some animal viral infections, although still not zoonotic, represent important economic loses to the livestock industry. Viral infections pose a genuine concern for which there has been an increasing interest for new antiviral molecules. Among these novel compounds, antiviral peptides have been proposed as promising therapeutic options, not only for the growing body of evidence showing hopeful results but also due to the many adverse effects of chemical-based drugs. Here we review the current progress, key targets and considerations for the development of antiviral peptides (AVPs). The review summarizes the state of the art of the AVPs tested in zoonotic (coronaviruses, Rift Valley fever viruses, Eastern Equine Encephalitis Virus, Dengue and Junin virus) and also non-zoonotic farm animal viruses (avian and cattle viruses). Their molecular target, amino acid sequence and mechanism of action are summarized and reviewed. Antiviral peptides are currently on the cutting edge since they have been reported to display anti-coronavirus activity. Particularly, the review will discuss the specific mode of action of AVPs that specifically inhibit the fusion of viral and host-cell membranes for SARS-CoV-2, showing in detail some important features of the fusion inhibiting peptides that target the spike protein of these risky viruses.
  • |Animals[MESH]
  • |Antiviral Agents/pharmacology[MESH]
  • |Dengue Virus/drug effects[MESH]
  • |Encephalitis Virus, Eastern Equine/drug effects[MESH]
  • |Humans[MESH]
  • |Junin virus/drug effects[MESH]
  • |Peptides/*pharmacology[MESH]
  • |Rift Valley fever virus/drug effects[MESH]
  • |SARS-CoV-2/drug effects[MESH]
  • |Viral Zoonoses/*drug therapy[MESH]


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