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10.24272/j.issn.2095-8137.2021.088 http://scihub22266oqcxt.onion/10.24272/j.issn.2095-8137.2021.088 33998180!8175951!33998180     free     free     free Deprecated: Implicit conversion from float 235.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 235.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 235.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 235.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 235.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 235.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 235.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Warning: imagejpeg(C:\Inetpub\vhosts\kidney.de\httpdocs\phplern\33998180.jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117       Zool+Res 2021 ; 42 (3): 335-338 Nephropedia Template TP {{tp|p=33998180|t=2021. Particulate matter exposure exacerbates susceptibility to SARS-CoV-2 infection in humanized ACE2 mice |pdf=|usr=}}{{33998180}} gab.com Text Particulate matter exposure exacerbates susceptibility to SARS-CoV-2 infection in humanized ACE2 mice JO: Zool Res http://www.kidney.de/pget.php?&tw=1&pmid=33998180 #FOAvip The global outbreak of coronavirus disease 2019 (COVID-19), which is caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), as of 8 May 2021, has surpassed 150 700 000 infections and 3 279 000 deaths worldwide. Evidence indicates that SARS-CoV-2 RNA can be detected on particulate matter (PM), and COVID-19 cases are correlated with levels of air pollutants. However, the mechanisms of PM involvement in the spread of SARS-CoV-2 remain poorly understood. Here, we found that PM exposure increased the expression level of angiotensin-converting enzyme 2 (ACE2) and transmembrane serine protease 2 (TMPRSS2) in several epithelial cells and increased the adsorption of the SARS-CoV-2 spike protein. Instillation of PM in a hACE2 mouse model significantly increased the expression of ACE2 and Tmprss2 and viral replication in the lungs. Furthermore, PM exacerbated the pulmonary lesions caused by SARS-CoV-2 infection in the hACE2 mice. In conclusion, our study demonstrated that PM is an epidemiological factor of COVID-19, emphasizing the necessity of wearing anti-PM masks to cope with this global pandemic. Twit Text FOAVip Particulate matter exposure exacerbates susceptibility to SARS-CoV-2 infection in humanized ACE2 mice ????Zool Res http://www.kidney.de/pget.php?&tw=1&pmid=33998180 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=33998180 #FOAvip English Wikipedia <ref>{{Cite pmid|33998180}}</ref> Particulate matter exposure exacerbates susceptibility to SARS-CoV-2 infection in humanized ACE2 mice #MMPMID33998180 Zhu TY; Qiu H; Cao QQ; Duan ZL; Liu FL; Song TZ; Liu Y; Fang YQ; Wu GM; Zheng YT; Ding WJ; Lai R; Jin L Zool Res 2021[May]; 42 (3): 335-338 PMID33998180show ga The global outbreak of coronavirus disease 2019 (COVID-19), which is caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), as of 8 May 2021, has surpassed 150 700 000 infections and 3 279 000 deaths worldwide. Evidence indicates that SARS-CoV-2 RNA can be detected on particulate matter (PM), and COVID-19 cases are correlated with levels of air pollutants. However, the mechanisms of PM involvement in the spread of SARS-CoV-2 remain poorly understood. Here, we found that PM exposure increased the expression level of angiotensin-converting enzyme 2 (ACE2) and transmembrane serine protease 2 (TMPRSS2) in several epithelial cells and increased the adsorption of the SARS-CoV-2 spike protein. Instillation of PM in a hACE2 mouse model significantly increased the expression of ACE2 and Tmprss2 and viral replication in the lungs. Furthermore, PM exacerbated the pulmonary lesions caused by SARS-CoV-2 infection in the hACE2 mice. In conclusion, our study demonstrated that PM is an epidemiological factor of COVID-19, emphasizing the necessity of wearing anti-PM masks to cope with this global pandemic. |*SARS-CoV-2/genetics[MESH] |Adsorption/drug effects[MESH] |Angiotensin-Converting Enzyme 2/*metabolism[MESH] |Animals[MESH] |COVID-19/*chemically induced/*immunology[MESH] |Disease Susceptibility/chemically induced/immunology[MESH] |Epithelial Cells/metabolism[MESH] |Mice[MESH] |Mice, Inbred Strains[MESH] |Particulate Matter/*adverse effects/chemistry[MESH] |RNA, Viral/analysis[MESH] |Serine Endopeptidases/metabolism[MESH] |Spike Glycoprotein, Coronavirus/metabolism[MESH]Particulate matter exposure exacerbates susceptibility to SARS-CoV-2 i(epmc).pdf DeepDyve Pubget Overpricing