Use my Search Websuite to scan PubMed, PMCentral, Journal Hosts and Journal Archives, FullText. Kick-your-searchterm to multiple Engines kick-your-query now !>

A dictionary by aggregated review articles of nephrology, medicine and the life sciences Your one-stop-run pathway from word to the immediate pdf of peer-reviewed on-topic knowledge.

10.1016/j.xcrm.2021.100296 http://scihub22266oqcxt.onion/10.1016/j.xcrm.2021.100296 33997824!8106889!33997824     free     free     free Deprecated: Implicit conversion from float 229.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 229.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 229.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Cell+Rep+Med 2021 ; 2 (6): 100296 Nephropedia Template TP {{tp|p=33997824|t=2021. Decay of Fc-dependent antibody functions after mild to moderate COVID-19 |pdf=|usr=}}{{33997824}} gab.com Text Decay of Fc-dependent antibody functions after mild to moderate COVID-19 JO: Cell Rep Med http://www.kidney.de/pget.php?&tw=1&pmid=33997824 #FOAvip The capacity of antibodies to engage with immune cells via the Fc region is important in preventing and controlling many infectious diseases. The evolution of such antibodies during convalescence from coronavirus disease 2019 (COVID-19) is largely unknown. We develop assays to measure Fc-dependent antibody functions against severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) spike (S)-expressing cells in serial samples from subjects primarily with mild-moderate COVID-19 up to 149 days post-infection. We find that S-specific antibodies capable of engaging Fcgamma receptors decay over time, with S-specific antibody-dependent cellular cytotoxicity (ADCC) and antibody-dependent phagocytosis (ADP) activity within plasma declining accordingly. Although there is significant decay in ADCC and ADP activity, they remain readily detectable in almost all subjects at the last time point studied (94%) in contrast with neutralization activity (70%). Although it remains unclear the degree to which Fc effector functions contribute to protection against SARS-CoV-2 re-infection, our results indicate that antibodies with Fc effector functions persist longer than neutralizing antibodies. Twit Text FOAVip Decay of Fc-dependent antibody functions after mild to moderate COVID-19 ????Cell Rep Med http://www.kidney.de/pget.php?&tw=1&pmid=33997824 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=33997824 #FOAvip English Wikipedia <ref>{{Cite pmid|33997824}}</ref> Decay of Fc-dependent antibody functions after mild to moderate COVID-19 #MMPMID33997824 Lee WS; Selva KJ; Davis SK; Wines BD; Reynaldi A; Esterbauer R; Kelly HG; Haycroft ER; Tan HX; Juno JA; Wheatley AK; Hogarth PM; Cromer D; Davenport MP; Chung AW; Kent SJ Cell Rep Med 2021[Jun]; 2 (6): 100296 PMID33997824show ga The capacity of antibodies to engage with immune cells via the Fc region is important in preventing and controlling many infectious diseases. The evolution of such antibodies during convalescence from coronavirus disease 2019 (COVID-19) is largely unknown. We develop assays to measure Fc-dependent antibody functions against severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) spike (S)-expressing cells in serial samples from subjects primarily with mild-moderate COVID-19 up to 149 days post-infection. We find that S-specific antibodies capable of engaging Fcgamma receptors decay over time, with S-specific antibody-dependent cellular cytotoxicity (ADCC) and antibody-dependent phagocytosis (ADP) activity within plasma declining accordingly. Although there is significant decay in ADCC and ADP activity, they remain readily detectable in almost all subjects at the last time point studied (94%) in contrast with neutralization activity (70%). Although it remains unclear the degree to which Fc effector functions contribute to protection against SARS-CoV-2 re-infection, our results indicate that antibodies with Fc effector functions persist longer than neutralizing antibodies. |Antibodies, Viral/blood/*metabolism[MESH] |Antibody-Dependent Cell Cytotoxicity/immunology[MESH] |COVID-19/*immunology/pathology/virology[MESH] |Cell Line, Tumor[MESH] |Dimerization[MESH] |Humans[MESH] |Immunoglobulin Fc Fragments/genetics/immunology/*metabolism[MESH] |Kinetics[MESH] |Neutralization Tests[MESH] |Phagocytosis[MESH] |SARS-CoV-2/immunology/isolation & purification/metabolism[MESH] |Severity of Illness Index[MESH]Decay of Fc-dependent antibody functions after mild to moderate COVID-(epmc).pdf DeepDyve Pubget Overpricing