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10.1016/j.mgene.2021.100910 http://scihub22266oqcxt.onion/10.1016/j.mgene.2021.100910 33996501!8106235!33996501     free     free     free Deprecated: Implicit conversion from float 227.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 227.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 227.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Meta+Gene 2021 ; 29 (ä): 100910 Nephropedia Template TP {{tp|p=33996501|t=2021. Design of advanced siRNA therapeutics for the treatment of COVID-19 |pdf=|usr=}}{{33996501}} gab.com Text Design of advanced siRNA therapeutics for the treatment of COVID-19 JO: Meta Gene http://www.kidney.de/pget.php?&tw=1&pmid=33996501 #FOAvip COVID-19 is a newly emerged viral disease that is currently affecting the whole globe. A variety of therapeutic approaches are underway to block the SARS-CoV-2 virus. Among these methods, siRNAs could be a safe and specific option, as they have been tested against other viruses. siRNAs are a class of inhibitor RNAs that act promisingly as mRNA expression blockers and they can be designed to interfere with viral mRNA to block virus replication. In order to do this, we designed and evaluated the efficacy of six highly specific siRNAs, which target essential viral mRNAs with no predicted human genome off-targets. We observed a significant reduction in the copy number viral mRNAs after treatment with the siRNAs, and are expected to inhibit virus replication. We propose siRNAs as a potential co-therapy for acute SARS-CoV-2 infection. Twit Text FOAVip Design of advanced siRNA therapeutics for the treatment of COVID-19 ????Meta Gene http://www.kidney.de/pget.php?&tw=1&pmid=33996501 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=33996501 #FOAvip English Wikipedia <ref>{{Cite pmid|33996501}}</ref> Design of advanced siRNA therapeutics for the treatment of COVID-19 #MMPMID33996501 Niktab I; Haghparast M; Beigi MH; Megraw TL; Kiani A; Ghaedi K Meta Gene 2021[Sep]; 29 (ä): 100910 PMID33996501show ga COVID-19 is a newly emerged viral disease that is currently affecting the whole globe. A variety of therapeutic approaches are underway to block the SARS-CoV-2 virus. Among these methods, siRNAs could be a safe and specific option, as they have been tested against other viruses. siRNAs are a class of inhibitor RNAs that act promisingly as mRNA expression blockers and they can be designed to interfere with viral mRNA to block virus replication. In order to do this, we designed and evaluated the efficacy of six highly specific siRNAs, which target essential viral mRNAs with no predicted human genome off-targets. We observed a significant reduction in the copy number viral mRNAs after treatment with the siRNAs, and are expected to inhibit virus replication. We propose siRNAs as a potential co-therapy for acute SARS-CoV-2 infection. äDesign of advanced siRNA therapeutics for the treatment of COVID-19 (epmc).pdf DeepDyve Pubget Overpricing