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10.3389/fimmu.2021.589095

http://scihub22266oqcxt.onion/10.3389/fimmu.2021.589095
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33995341!8115911!33995341
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suck abstract from ncbi


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pmid33995341      Front+Immunol 2021 ; 12 (ä): 589095
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  • Cytokine Storm: The Primary Determinant for the Pathophysiological Evolution of COVID-19 Deterioration #MMPMID33995341
  • Chen R; Lan Z; Ye J; Pang L; Liu Y; Wu W; Qin X; Guo Y; Zhang P
  • Front Immunol 2021[]; 12 (ä): 589095 PMID33995341show ga
  • The coronavirus disease 2019 (COVID-19) pandemic caused by the novel severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is an ongoing major threat to global health and has posed significant challenges for the treatment of severely ill COVID-19 patients. Several studies have reported that cytokine storms are an important cause of disease deterioration and death in COVID-19 patients. Consequently, it is important to understand the specific pathophysiological processes underlying how cytokine storms promote the deterioration of COVID-19. Here, we outline the pathophysiological processes through which cytokine storms contribute to the deterioration of SARS-CoV-2 infection and describe the interaction between SARS-CoV-2 and the immune system, as well as the pathophysiology of immune response dysfunction that leads to acute respiratory distress syndrome (ARDS), multi-organ dysfunction syndrome (MODS), and coagulation impairment. Treatments based on inhibiting cytokine storm-induced deterioration and occurrence are also described.
  • |*COVID-19/epidemiology/immunology/pathology/physiopathology[MESH]
  • |*Cytokine Release Syndrome/epidemiology/immunology/pathology/physiopathology[MESH]
  • |*Pandemics[MESH]
  • |Humans[MESH]


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