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10.3389/fphar.2021.631879 http://scihub22266oqcxt.onion/10.3389/fphar.2021.631879 33995033!8114414!33995033     free     free     free Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 265.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 265.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Front+Pharmacol 2021 ; 12 (ä): 631879 Nephropedia Template TP {{tp|p=33995033|t=2021. SARS-CoV-2 Switches on MAPK and NFkappaB Signaling via the Reduction of Nuclear DUSP1 and DUSP5 Expression |pdf=|usr=}}{{33995033}} gab.com Text SARS-CoV-2 Switches on MAPK and NFkappaB Signaling via the Reduction of Nuclear DUSP1 and DUSP5 Expression JO: Front Pharmacol http://www.kidney.de/pget.php?&tw=1&pmid=33995033 #FOAvip Mitogen-activated protein kinases (MAPK) and NF-kappaB (NF-kappaB) pathway regulate many cellular processes and are essential for immune cells function. Their activity is controlled by dual-specificity phosphatases (DUSPs). A comprehensive analysis of publicly available gene expression data sets of human airway epithelial cells (AECs) infected with SARS-CoV-2 identified DUSP1 and DUSP5 among the lowest induced transcripts within these pathways. These proteins are known to downregulate MAPK and NF-kappaB pathways; and their lower expression was associated with increased activity of MAPK and NF-kappaB signaling and enhanced expression of proinflammatory cytokines such as TNF-alpha. Infection with other coronaviruses did not have a similar effect on these genes. Interestingly, treatment with chloroquine and/or non-steroidal anti-inflammatory drugs counteracted the SARS-CoV-2 induced reduction of DUSP1 and DUSP5 genes expression. Therapeutically, impeding this evasion mechanism of SARS-CoV-2 may help control the exaggerated activation of these immune regulatory pathways during a COVID-19 infection. Twit Text FOAVip SARS-CoV-2 Switches on MAPK and NFkappaB Signaling via the Reduction of Nuclear DUSP1 and DUSP5 Expression ????Front Pharmacol http://www.kidney.de/pget.php?&tw=1&pmid=33995033 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=33995033 #FOAvip English Wikipedia <ref>{{Cite pmid|33995033}}</ref> SARS-CoV-2 Switches on MAPK and NFkappaB Signaling via the Reduction of Nuclear DUSP1 and DUSP5 Expression #MMPMID33995033 Goel S; Saheb Sharif-Askari F; Saheb Sharif Askari N; Madkhana B; Alwaa AM; Mahboub B; Zakeri AM; Ratemi E; Hamoudi R; Hamid Q; Halwani R Front Pharmacol 2021[]; 12 (ä): 631879 PMID33995033show ga Mitogen-activated protein kinases (MAPK) and NF-kappaB (NF-kappaB) pathway regulate many cellular processes and are essential for immune cells function. Their activity is controlled by dual-specificity phosphatases (DUSPs). A comprehensive analysis of publicly available gene expression data sets of human airway epithelial cells (AECs) infected with SARS-CoV-2 identified DUSP1 and DUSP5 among the lowest induced transcripts within these pathways. These proteins are known to downregulate MAPK and NF-kappaB pathways; and their lower expression was associated with increased activity of MAPK and NF-kappaB signaling and enhanced expression of proinflammatory cytokines such as TNF-alpha. Infection with other coronaviruses did not have a similar effect on these genes. Interestingly, treatment with chloroquine and/or non-steroidal anti-inflammatory drugs counteracted the SARS-CoV-2 induced reduction of DUSP1 and DUSP5 genes expression. Therapeutically, impeding this evasion mechanism of SARS-CoV-2 may help control the exaggerated activation of these immune regulatory pathways during a COVID-19 infection. äSARS-CoV-2 Switches on MAPK and NFkappaB Signaling via the Reduction(epmc).pdf DeepDyve Pubget Overpricing