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10.1038/s41392-021-00567-7 http://scihub22266oqcxt.onion/10.1038/s41392-021-00567-7 33994545!8126563!33994545     free     free     free Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Signal+Transduct+Target+Ther 2021 ; 6 (1): 183 Nephropedia Template TP {{tp|p=33994545|t=2021. Protein kinase CK2: a potential therapeutic target for diverse human diseases |pdf=|usr=}}{{33994545}} gab.com Text Protein kinase CK2: a potential therapeutic target for diverse human diseases JO: Signal Transduct Target Ther http://www.kidney.de/pget.php?&tw=1&pmid=33994545 #FOAvip CK2 is a constitutively active Ser/Thr protein kinase, which phosphorylates hundreds of substrates, controls several signaling pathways, and is implicated in a plethora of human diseases. Its best documented role is in cancer, where it regulates practically all malignant hallmarks. Other well-known functions of CK2 are in human infections; in particular, several viruses exploit host cell CK2 for their life cycle. Very recently, also SARS-CoV-2, the virus responsible for the COVID-19 pandemic, has been found to enhance CK2 activity and to induce the phosphorylation of several CK2 substrates (either viral and host proteins). CK2 is also considered an emerging target for neurological diseases, inflammation and autoimmune disorders, diverse ophthalmic pathologies, diabetes, and obesity. In addition, CK2 activity has been associated with cardiovascular diseases, as cardiac ischemia-reperfusion injury, atherosclerosis, and cardiac hypertrophy. The hypothesis of considering CK2 inhibition for cystic fibrosis therapies has been also entertained for many years. Moreover, psychiatric disorders and syndromes due to CK2 mutations have been recently identified. On these bases, CK2 is emerging as an increasingly attractive target in various fields of human medicine, with the advantage that several very specific and effective inhibitors are already available. Here, we review the literature on CK2 implication in different human pathologies and evaluate its potential as a pharmacological target in the light of the most recent findings. Twit Text FOAVip Protein kinase CK2: a potential therapeutic target for diverse human diseases ????Signal Transduct Target Ther http://www.kidney.de/pget.php?&tw=1&pmid=33994545 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=33994545 #FOAvip English Wikipedia <ref>{{Cite pmid|33994545}}</ref> Protein kinase CK2: a potential therapeutic target for diverse human diseases #MMPMID33994545 Borgo C; D'Amore C; Sarno S; Salvi M; Ruzzene M Signal Transduct Target Ther 2021[May]; 6 (1): 183 PMID33994545show ga CK2 is a constitutively active Ser/Thr protein kinase, which phosphorylates hundreds of substrates, controls several signaling pathways, and is implicated in a plethora of human diseases. Its best documented role is in cancer, where it regulates practically all malignant hallmarks. Other well-known functions of CK2 are in human infections; in particular, several viruses exploit host cell CK2 for their life cycle. Very recently, also SARS-CoV-2, the virus responsible for the COVID-19 pandemic, has been found to enhance CK2 activity and to induce the phosphorylation of several CK2 substrates (either viral and host proteins). CK2 is also considered an emerging target for neurological diseases, inflammation and autoimmune disorders, diverse ophthalmic pathologies, diabetes, and obesity. In addition, CK2 activity has been associated with cardiovascular diseases, as cardiac ischemia-reperfusion injury, atherosclerosis, and cardiac hypertrophy. The hypothesis of considering CK2 inhibition for cystic fibrosis therapies has been also entertained for many years. Moreover, psychiatric disorders and syndromes due to CK2 mutations have been recently identified. On these bases, CK2 is emerging as an increasingly attractive target in various fields of human medicine, with the advantage that several very specific and effective inhibitors are already available. Here, we review the literature on CK2 implication in different human pathologies and evaluate its potential as a pharmacological target in the light of the most recent findings. |*COVID-19 Drug Treatment[MESH] |*COVID-19/enzymology/genetics[MESH] |*Cardiovascular Diseases/drug therapy/enzymology/genetics[MESH] |*Casein Kinase II/antagonists & inhibitors/genetics/metabolism[MESH] |*Cystic Fibrosis/drug therapy/enzymology/genetics[MESH] |*Eye Diseases/drug therapy/enzymology/genetics[MESH] |*Mental Disorders/drug therapy/enzymology/genetics[MESH] |*SARS-CoV-2[MESH] |Humans[MESH] |Mutation[MESH] |Phosphorylation[MESH] |Protein Kinase Inhibitors/*therapeutic use[MESH]Protein kinase CK2: a potential therapeutic target for diverse human d(epmc).pdf DeepDyve Pubget Overpricing