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10.1080/22221751.2021.1931466 http://scihub22266oqcxt.onion/10.1080/22221751.2021.1931466 33993845!8172228!33993845     free     free     free Warning: file_get_contents(https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&id=33993845&cmd=llinks): Failed to open stream: HTTP request failed! 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Prime-boost vaccination of mice and rhesus macaques with two novel adenovirus vectored COVID-19 vaccine candidates |pdf=|usr=}}{{33993845}} gab.com Text Prime-boost vaccination of mice and rhesus macaques with two novel adenovirus vectored COVID-19 vaccine candidates JO: Emerg Microbes Infect http://www.kidney.de/pget.php?&tw=1&pmid=33993845 #FOAvip ABSTRACTCOVID-19 vaccines are being developed urgently worldwide. Here, we constructed two adenovirus vectored COVID-19 vaccine candidates of Sad23L-nCoV-S and Ad49L-nCoV-S carrying the full-length gene of SARS-CoV-2 spike protein. The immunogenicity of two vaccines was individually evaluated in mice. Specific immune responses were observed by priming in a dose-dependent manner, and stronger responses were obtained by boosting. Furthermore, five rhesus macaques were primed with 5 x 10(9) PFU Sad23L-nCoV-S, followed by boosting with 5 x 10(9) PFU Ad49L-nCoV-S at 4-week interval. Both mice and macaques well tolerated the vaccine inoculations without detectable clinical or pathologic changes. In macaques, prime-boost regimen induced high titers of 10(3.16) anti-S, 10(2.75) anti-RBD binding antibody and 10(2.38) pseudovirus neutralizing antibody (pNAb) at 2 months, while pNAb decreased gradually to 10(1.45) at 7 months post-priming. Robust T-cell response of IFN-gamma (712.6 SFCs/10(6) cells), IL-2 (334 SFCs/10(6) cells) and intracellular IFN-gamma in CD4(+)/CD8(+) T cell (0.39%/0.55%) to S peptides were detected in vaccinated macaques. It was concluded that prime-boost immunization with Sad23L-nCoV-S and Ad49L-nCoV-S can safely elicit strong immunity in animals in preparation of clinical phase 1/2 trials. Twit Text FOAVip Prime-boost vaccination of mice and rhesus macaques with two novel adenovirus vectored COVID-19 vaccine candidates ????Emerg Microbes Infect http://www.kidney.de/pget.php?&tw=1&pmid=33993845 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=33993845 #FOAvip English Wikipedia <ref>{{Cite pmid|33993845}}</ref> Prime-boost vaccination of mice and rhesus macaques with two novel adenovirus vectored COVID-19 vaccine candidates #MMPMID33993845 Luo S; Zhang P; Liu B; Yang C; Liang C; Wang Q; Zhang L; Tang X; Li J; Hou S; Zeng J; Fu Y; Allain JP; Li T; Zhang Y; Li C Emerg Microbes Infect 2021[Dec]; 10 (1): 1002-1015 PMID33993845show ga ABSTRACTCOVID-19 vaccines are being developed urgently worldwide. Here, we constructed two adenovirus vectored COVID-19 vaccine candidates of Sad23L-nCoV-S and Ad49L-nCoV-S carrying the full-length gene of SARS-CoV-2 spike protein. The immunogenicity of two vaccines was individually evaluated in mice. Specific immune responses were observed by priming in a dose-dependent manner, and stronger responses were obtained by boosting. Furthermore, five rhesus macaques were primed with 5 x 10(9) PFU Sad23L-nCoV-S, followed by boosting with 5 x 10(9) PFU Ad49L-nCoV-S at 4-week interval. Both mice and macaques well tolerated the vaccine inoculations without detectable clinical or pathologic changes. In macaques, prime-boost regimen induced high titers of 10(3.16) anti-S, 10(2.75) anti-RBD binding antibody and 10(2.38) pseudovirus neutralizing antibody (pNAb) at 2 months, while pNAb decreased gradually to 10(1.45) at 7 months post-priming. Robust T-cell response of IFN-gamma (712.6 SFCs/10(6) cells), IL-2 (334 SFCs/10(6) cells) and intracellular IFN-gamma in CD4(+)/CD8(+) T cell (0.39%/0.55%) to S peptides were detected in vaccinated macaques. It was concluded that prime-boost immunization with Sad23L-nCoV-S and Ad49L-nCoV-S can safely elicit strong immunity in animals in preparation of clinical phase 1/2 trials. |*Immunization, Secondary[MESH] |Adenoviridae/genetics[MESH] |Animals[MESH] |Antibodies, Neutralizing/blood[MESH] |Antibodies, Viral/blood[MESH] |COVID-19 Vaccines/adverse effects/*immunology[MESH] |COVID-19/*prevention & control[MESH] |Female[MESH] |Genetic Vectors[MESH] |HEK293 Cells[MESH] |Humans[MESH] |Macaca mulatta[MESH] |Male[MESH] |Mice[MESH] |Mice, Inbred BALB C[MESH] |Mice, Inbred C57BL[MESH] |SARS-CoV-2/*immunology[MESH]Prime-boost vaccination of mice and rhesus macaques with two novel ade(epmc).pdf DeepDyve Pubget Overpricing