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10.1186/s12879-021-06156-x

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33992073!8122196!33992073
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suck abstract from ncbi


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pmid33992073      BMC+Infect+Dis 2021 ; 21 (1): 443
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  • Dynamics of anti-SARS-CoV-2 IgG antibodies post-COVID-19 in a Brazilian Amazon population #MMPMID33992073
  • Bichara CDA; da Silva Graca Amoras E; Vaz GL; da Silva Torres MK; Queiroz MAF; do Amaral IPC; Vallinoto IMVC; Bichara CNC; Vallinoto ACR
  • BMC Infect Dis 2021[May]; 21 (1): 443 PMID33992073show ga
  • BACKGROUND: In this study, the prevalence and persistence of anti-SARS-CoV-2 (severe acute respiratory syndrome-coronavirus) IgG was evaluated in volunteers 90 days after COVID-19 (coronavirus disease 2019) diagnosis by correlating response dynamics with clinical conditions, epidemiological characteristics, and disease severity. METHODS: The study recruited 200 volunteers aged 18 years or older of both sexes diagnosed with COVID-19. Of the 200 volunteers initially selected, the 135 individuals who underwent serological testing for anti-SARS-CoV-2 antibodies on the first visit to the laboratory, were invited to return, after 90 days, and provide a new blood sample for a second assessment of the presence of anti-SARS-CoV-2 IgG antibody. Disease severity and longevity of symptoms were evaluated for each individual and associated with the serological profile. RESULTS: Among the 135 individuals who underwent a previous serological test for anti-SARS-CoV-2 antibody, 125 showed reactivity to IgG (92.6%). Of the 125 individuals with detectable IgG in the first test, 87 (69.6%) showed persistence of this antibody after 90 days and 38 (30.4%) lost IgG reactivity in the second evaluation. The frequency of all reported symptoms was higher in individuals who maintained IgG persistence after 90 days of symptoms. Symptom manifestations lasted >/=21 days in the group with a persistent IgG response (39.6%) and
  • |*Severity of Illness Index[MESH]
  • |Adult[MESH]
  • |Aged[MESH]
  • |Aged, 80 and over[MESH]
  • |Antibodies, Viral/*blood[MESH]
  • |Brazil/epidemiology[MESH]
  • |COVID-19 Serological Testing/*methods[MESH]
  • |COVID-19/*blood/*epidemiology/immunology/virology[MESH]
  • |Cross-Sectional Studies[MESH]
  • |Female[MESH]
  • |Humans[MESH]
  • |Immunoglobulin G/*blood[MESH]
  • |Male[MESH]
  • |Middle Aged[MESH]
  • |SARS-CoV-2/*immunology[MESH]


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