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10.1016/j.cmi.2021.05.006 http://scihub22266oqcxt.onion/10.1016/j.cmi.2021.05.006 33991677!8114812!33991677     free     free     free Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Clin+Microbiol+Infect 2021 ; 27 (9): 1352.e1-1352.e5 Nephropedia Template TP {{tp|p=33991677|t=2021. Spreading of a new SARS-CoV-2 N501Y spike variant in a new lineage |pdf=|usr=}}{{33991677}} gab.com Text Spreading of a new SARS-CoV-2 N501Y spike variant in a new lineage JO: Clin Microbiol Infect http://www.kidney.de/pget.php?&tw=1&pmid=33991677 #FOAvip OBJECTIVES: Surveillance of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) genomic epidemiology led us to detect several variants since summer 2020. We report the recent spread of a new SARS-CoV-2 spike 501Y variant. METHODS: SARS-CoV-2 sequences obtained from human nasopharyngeal samples by Illumina next-generation sequencing were analysed using Nextclade and an in-house Python script and were compared using BLASTn to the GISAID database. Phylogeny was investigated using the IQ-TREE software. RESULTS: We identified that SARS-CoV-2 genomes from four patients diagnosed in our institute harboured a new set of amino acid substitutions including L18F, L452R, N501Y, A653V, H655Y, D796Y, G1219V +/- Q677H. These spike N501Y genomes are the first of Nextstrain clade 19B. We obtained partial spike gene sequences of this genotype for an additional 43 patients. All patients infected with this genotype were diagnosed since mid-January 2021. We detected 42 other genomes of this genotype in GISAID, which were obtained from samples collected in December 2020 in four individuals and in 2021 in 38 individuals. The 89 sequences obtained in our institute or other laboratories originated from the Comoros archipelago, western European countries (mostly metropolitan France), Turkey and Nigeria. CONCLUSION: These findings warrant further studies to investigate the spread, epidemiological and clinical features, and sensitivity to immune responses of this variant. Twit Text FOAVip Spreading of a new SARS-CoV-2 N501Y spike variant in a new lineage ????Clin Microbiol Infect http://www.kidney.de/pget.php?&tw=1&pmid=33991677 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=33991677 #FOAvip English Wikipedia <ref>{{Cite pmid|33991677}}</ref> Spreading of a new SARS-CoV-2 N501Y spike variant in a new lineage #MMPMID33991677 Colson P; Levasseur A; Delerce J; Pinault L; Dudouet P; Devaux C; Fournier PE; La Scola B; Lagier JC; Raoult D Clin Microbiol Infect 2021[Sep]; 27 (9): 1352.e1-1352.e5 PMID33991677show ga OBJECTIVES: Surveillance of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) genomic epidemiology led us to detect several variants since summer 2020. We report the recent spread of a new SARS-CoV-2 spike 501Y variant. METHODS: SARS-CoV-2 sequences obtained from human nasopharyngeal samples by Illumina next-generation sequencing were analysed using Nextclade and an in-house Python script and were compared using BLASTn to the GISAID database. Phylogeny was investigated using the IQ-TREE software. RESULTS: We identified that SARS-CoV-2 genomes from four patients diagnosed in our institute harboured a new set of amino acid substitutions including L18F, L452R, N501Y, A653V, H655Y, D796Y, G1219V +/- Q677H. These spike N501Y genomes are the first of Nextstrain clade 19B. We obtained partial spike gene sequences of this genotype for an additional 43 patients. All patients infected with this genotype were diagnosed since mid-January 2021. We detected 42 other genomes of this genotype in GISAID, which were obtained from samples collected in December 2020 in four individuals and in 2021 in 38 individuals. The 89 sequences obtained in our institute or other laboratories originated from the Comoros archipelago, western European countries (mostly metropolitan France), Turkey and Nigeria. CONCLUSION: These findings warrant further studies to investigate the spread, epidemiological and clinical features, and sensitivity to immune responses of this variant. |*Amino Acid Substitution[MESH] |COVID-19/*diagnosis[MESH] |France[MESH] |High-Throughput Nucleotide Sequencing[MESH] |Humans[MESH] |Models, Molecular[MESH] |Nasopharynx/virology[MESH] |Nigeria[MESH] |Phylogeny[MESH] |Protein Conformation[MESH] |SARS-CoV-2/*classification/genetics[MESH] |Sequence Analysis, RNA/*methods[MESH] |Spike Glycoprotein, Coronavirus/chemistry/*genetics[MESH]Spreading of a new SARS-CoV-2 N501Y spike variant in a new lineage (epmc).pdf DeepDyve Pubget Overpricing