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10.1016/j.cell.2021.04.025 http://scihub22266oqcxt.onion/10.1016/j.cell.2021.04.025 33991487!8057738!33991487     free     free     free Deprecated: Implicit conversion from float 235.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 235.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 235.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Cell 2021 ; 184 (13): 3426-3437.e8 Nephropedia Template TP {{tp|p=33991487|t=2021. Transmission, infectivity, and neutralization of a spike L452R SARS-CoV-2 variant |pdf=|usr=}}{{33991487}} gab.com Text Transmission, infectivity, and neutralization of a spike L452R SARS-CoV-2 variant JO: Cell http://www.kidney.de/pget.php?&tw=1&pmid=33991487 #FOAvip We identified an emerging severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) variant by viral whole-genome sequencing of 2,172 nasal/nasopharyngeal swab samples from 44 counties in California, a state in the western United States. Named B.1.427/B.1.429 to denote its two lineages, the variant emerged in May 2020 and increased from 0% to >50% of sequenced cases from September 2020 to January 2021, showing 18.6%-24% increased transmissibility relative to wild-type circulating strains. The variant carries three mutations in the spike protein, including an L452R substitution. We found 2-fold increased B.1.427/B.1.429 viral shedding in vivo and increased L452R pseudovirus infection of cell cultures and lung organoids, albeit decreased relative to pseudoviruses carrying the N501Y mutation common to variants B.1.1.7, B.1.351, and P.1. Antibody neutralization assays revealed 4.0- to 6.7-fold and 2.0-fold decreases in neutralizing titers from convalescent patients and vaccine recipients, respectively. The increased prevalence of a more transmissible variant in California exhibiting decreased antibody neutralization warrants further investigation. Twit Text FOAVip Transmission, infectivity, and neutralization of a spike L452R SARS-CoV-2 variant ????Cell http://www.kidney.de/pget.php?&tw=1&pmid=33991487 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=33991487 #FOAvip English Wikipedia <ref>{{Cite pmid|33991487}}</ref> Transmission, infectivity, and neutralization of a spike L452R SARS-CoV-2 variant #MMPMID33991487 Deng X; Garcia-Knight MA; Khalid MM; Servellita V; Wang C; Morris MK; Sotomayor-Gonzalez A; Glasner DR; Reyes KR; Gliwa AS; Reddy NP; Sanchez San Martin C; Federman S; Cheng J; Balcerek J; Taylor J; Streithorst JA; Miller S; Sreekumar B; Chen PY; Schulze-Gahmen U; Taha TY; Hayashi JM; Simoneau CR; Kumar GR; McMahon S; Lidsky PV; Xiao Y; Hemarajata P; Green NM; Espinosa A; Kath C; Haw M; Bell J; Hacker JK; Hanson C; Wadford DA; Anaya C; Ferguson D; Frankino PA; Shivram H; Lareau LF; Wyman SK; Ott M; Andino R; Chiu CY Cell 2021[Jun]; 184 (13): 3426-3437.e8 PMID33991487show ga We identified an emerging severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) variant by viral whole-genome sequencing of 2,172 nasal/nasopharyngeal swab samples from 44 counties in California, a state in the western United States. Named B.1.427/B.1.429 to denote its two lineages, the variant emerged in May 2020 and increased from 0% to >50% of sequenced cases from September 2020 to January 2021, showing 18.6%-24% increased transmissibility relative to wild-type circulating strains. The variant carries three mutations in the spike protein, including an L452R substitution. We found 2-fold increased B.1.427/B.1.429 viral shedding in vivo and increased L452R pseudovirus infection of cell cultures and lung organoids, albeit decreased relative to pseudoviruses carrying the N501Y mutation common to variants B.1.1.7, B.1.351, and P.1. Antibody neutralization assays revealed 4.0- to 6.7-fold and 2.0-fold decreases in neutralizing titers from convalescent patients and vaccine recipients, respectively. The increased prevalence of a more transmissible variant in California exhibiting decreased antibody neutralization warrants further investigation. |Antibodies, Monoclonal/immunology[MESH] |Antibodies, Neutralizing/*immunology[MESH] |Antibodies, Viral/immunology[MESH] |COVID-19/*immunology/*transmission[MESH] |Humans[MESH] |Mutation/genetics[MESH] |SARS-CoV-2/*genetics[MESH] |Spike Glycoprotein, Coronavirus/*immunology[MESH]Transmission, infectivity, and neutralization of a spike L452R SARS-Co(epmc).pdf DeepDyve Pubget Overpricing