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10.1371/journal.pone.0251768 http://scihub22266oqcxt.onion/10.1371/journal.pone.0251768 33989341!8121324!33989341     free     free     free Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       PLoS+One 2021 ; 16 (5): e0251768 Nephropedia Template TP {{tp|p=33989341|t=2021. The impact of chest CT body composition parameters on clinical outcomes in COVID-19 patients |pdf=|usr=}}{{33989341}} gab.com Text The impact of chest CT body composition parameters on clinical outcomes in COVID-19 patients JO: PLoS One http://www.kidney.de/pget.php?&tw=1&pmid=33989341 #FOAvip We assessed the impact of chest CT body composition parameters on outcomes and disease severity at hospital presentation of COVID-19 patients, focusing also on the possible mediation of body composition in the relationship between age and death in these patients. Chest CT scans performed at hospital presentation by consecutive COVID-19 patients (02/27/2020-03/13/2020) were retrospectively reviewed to obtain pectoralis muscle density and total, visceral, and intermuscular adipose tissue areas (TAT, VAT, IMAT) at the level of T7-T8 vertebrae. Primary outcomes were: hospitalization, mechanical ventilation (MV) and/or death, death alone. Secondary outcomes were: C-reactive protein (CRP), oxygen saturation (SO2), CT disease extension at hospital presentation. The mediation of body composition in the effect of age on death was explored. Of the 318 patients included in the study (median age 65.7 years, females 37.7%), 205 (64.5%) were hospitalized, 68 (21.4%) needed MV, and 58 (18.2%) died. Increased muscle density was a protective factor while increased TAT, VAT, and IMAT were risk factors for hospitalization and MV/death. All these parameters except TAT had borderline effects on death alone. All parameters were associated with SO2 and extension of lung parenchymal involvement at CT; VAT was associated with CRP. Approximately 3% of the effect of age on death was mediated by decreased muscle density. In conclusion, low muscle quality and ectopic fat accumulation were associated with COVID-19 outcomes, VAT was associated with baseline inflammation. Low muscle quality partly mediated the effect of age on mortality. Twit Text FOAVip The impact of chest CT body composition parameters on clinical outcomes in COVID-19 patients ????PLoS One http://www.kidney.de/pget.php?&tw=1&pmid=33989341 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=33989341 #FOAvip English Wikipedia <ref>{{Cite pmid|33989341}}</ref> The impact of chest CT body composition parameters on clinical outcomes in COVID-19 patients #MMPMID33989341 Besutti G; Pellegrini M; Ottone M; Cantini M; Milic J; Bonelli E; Dolci G; Cassone G; Ligabue G; Spaggiari L; Pattacini P; Fasano T; Canovi S; Massari M; Salvarani C; Guaraldi G; Rossi PG PLoS One 2021[]; 16 (5): e0251768 PMID33989341show ga We assessed the impact of chest CT body composition parameters on outcomes and disease severity at hospital presentation of COVID-19 patients, focusing also on the possible mediation of body composition in the relationship between age and death in these patients. Chest CT scans performed at hospital presentation by consecutive COVID-19 patients (02/27/2020-03/13/2020) were retrospectively reviewed to obtain pectoralis muscle density and total, visceral, and intermuscular adipose tissue areas (TAT, VAT, IMAT) at the level of T7-T8 vertebrae. Primary outcomes were: hospitalization, mechanical ventilation (MV) and/or death, death alone. Secondary outcomes were: C-reactive protein (CRP), oxygen saturation (SO2), CT disease extension at hospital presentation. The mediation of body composition in the effect of age on death was explored. Of the 318 patients included in the study (median age 65.7 years, females 37.7%), 205 (64.5%) were hospitalized, 68 (21.4%) needed MV, and 58 (18.2%) died. Increased muscle density was a protective factor while increased TAT, VAT, and IMAT were risk factors for hospitalization and MV/death. All these parameters except TAT had borderline effects on death alone. All parameters were associated with SO2 and extension of lung parenchymal involvement at CT; VAT was associated with CRP. Approximately 3% of the effect of age on death was mediated by decreased muscle density. In conclusion, low muscle quality and ectopic fat accumulation were associated with COVID-19 outcomes, VAT was associated with baseline inflammation. Low muscle quality partly mediated the effect of age on mortality. |*Body Composition[MESH] |Aged[MESH] |Aged, 80 and over[MESH] |Body Mass Index[MESH] |COVID-19/*diagnostic imaging/epidemiology/*mortality/virology[MESH] |Female[MESH] |Hospitalization[MESH] |Humans[MESH] |Intra-Abdominal Fat/*diagnostic imaging[MESH] |Italy/epidemiology[MESH] |Male[MESH] |Mass Chest X-Ray/*methods[MESH] |Middle Aged[MESH] |Respiration, Artificial[MESH] |Retrospective Studies[MESH] |Risk Factors[MESH] |SARS-CoV-2/*genetics[MESH] |Tomography, X-Ray Computed/*methods[MESH]The impact of chest CT body composition parameters on clinical outcome(epmc).pdf DeepDyve Pubget Overpricing