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COVID-19 in transplant recipient children: An Iranian referral hospital-based study #MMPMID33988141
Ghazizadeh Esslami G; Mamishi S; Mahmoudi S; Navaeian A; Behfar M; Hamidieh AA; Alimadadi H; Mahmoudieh Y
Acta Biomed 2021[May]; 92 (2): e2021095 PMID33988141show ga
To our knowledge, there is still very limited information on the severity, mortality, laboratory, and radiologic findings of COVID-19 infection in transplant patients, particularly children. In this study, we report and analyze 7 transplant recipients with laboratory-confirmed COVID-19 infection. The median age was 7.5 years (IQR: 31month-10 years), and 71% of the patients were male. All cases presented with a fever. The median duration of fever before admission was 2 days (IQR:1-8 days). Five patients (71%) experienced cough and dyspnea. Lymphocytopenia (Median of 0.6 (IQR: 0.14-2.0x 10(9) cells per L) and thrombocytopenia (Median of 65 (IQR: 49-201x 10(9) cells per L) were the most common CBC findings (both seen in 5 out of the 7 patients. Among 4 of the patients who underwent CT scans, 2 had ground glass opacity and consolidations. The mean number of lobe involvement in our patients was 3(0-5), and 75% of the cases showed bilateral lung involvement in the imaging. In 4 patients (51%) the disease course manifested severely, and 2 patients are now deceased (28.6%). In conclusion, immunocompromised pediatric subgroups may experience higher rates of disease severity and mortality in comparison with the immunocompetent pediatric population.
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Acta+Biomed 2021 ; 92 (2): e2021095
