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10.1038/s41541-021-00330-7 http://scihub22266oqcxt.onion/10.1038/s41541-021-00330-7 33986287!8119681!33986287     free     free     free Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       NPJ+Vaccines 2021 ; 6 (1): 70 Nephropedia Template TP {{tp|p=33986287|t=2021. Protein-based antigen presentation platforms for nanoparticle vaccines |pdf=|usr=}}{{33986287}} gab.com Text Protein-based antigen presentation platforms for nanoparticle vaccines JO: NPJ Vaccines http://www.kidney.de/pget.php?&tw=1&pmid=33986287 #FOAvip Modern vaccine design has sought a minimalization approach, moving to the isolation of antigens from pathogens that invoke a strong neutralizing immune response. This approach has created safer vaccines but may limit vaccine efficacy due to poor immunogenicity. To combat global diseases such as COVID-19, malaria, and AIDS there is a clear urgency for more effective next-generation vaccines. One approach to improve the immunogenicity of vaccines is the use of nanoparticle platforms that present a repetitive array of antigen on its surface. This technology has been shown to improve antigen presenting cell uptake, lymph node trafficking, and B-cell activation through increased avidity and particle size. With a focus on design, we summarize natural platforms, methods of antigen attachment, and advancements in generating self-assembly that have led to new engineered platforms. We further examine critical parameters that will direct the usage and development of more effective platforms. Twit Text FOAVip Protein-based antigen presentation platforms for nanoparticle vaccines ????NPJ Vaccines http://www.kidney.de/pget.php?&tw=1&pmid=33986287 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=33986287 #FOAvip English Wikipedia <ref>{{Cite pmid|33986287}}</ref> Protein-based antigen presentation platforms for nanoparticle vaccines #MMPMID33986287 Nguyen B; Tolia NH NPJ Vaccines 2021[May]; 6 (1): 70 PMID33986287show ga Modern vaccine design has sought a minimalization approach, moving to the isolation of antigens from pathogens that invoke a strong neutralizing immune response. This approach has created safer vaccines but may limit vaccine efficacy due to poor immunogenicity. To combat global diseases such as COVID-19, malaria, and AIDS there is a clear urgency for more effective next-generation vaccines. One approach to improve the immunogenicity of vaccines is the use of nanoparticle platforms that present a repetitive array of antigen on its surface. This technology has been shown to improve antigen presenting cell uptake, lymph node trafficking, and B-cell activation through increased avidity and particle size. With a focus on design, we summarize natural platforms, methods of antigen attachment, and advancements in generating self-assembly that have led to new engineered platforms. We further examine critical parameters that will direct the usage and development of more effective platforms. äProtein-based antigen presentation platforms for nanoparticle vaccines(epmc).pdf DeepDyve Pubget Overpricing