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10.1038/s41467-021-23166-0 http://scihub22266oqcxt.onion/10.1038/s41467-021-23166-0 33986286!8119425!33986286     free     free     free Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 265.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Nat+Commun 2021 ; 12 (1): 2790 Nephropedia Template TP {{tp|p=33986286|t=2021. Characterization of an attenuated SARS-CoV-2 variant with a deletion at the S1/S2 junction of the spike protein |pdf=|usr=}}{{33986286}} gab.com Text Characterization of an attenuated SARS-CoV-2 variant with a deletion at the S1/S2 junction of the spike protein JO: Nat Commun http://www.kidney.de/pget.php?&tw=1&pmid=33986286 #FOAvip SARS-CoV-2 is of zoonotic origin and contains a PRRA polybasic cleavage motif which is considered critical for efficient infection and transmission in humans. We previously reported on a panel of attenuated SARS-CoV-2 variants with deletions at the S1/S2 junction of the spike protein. Here, we characterize pathogenicity, immunogenicity, and protective ability of a further cell-adapted SARS-CoV-2 variant, Ca-DelMut, in in vitro and in vivo systems. Ca-DelMut replicates more efficiently than wild type or parental virus in Vero E6 cells, but causes no apparent disease in hamsters, despite replicating in respiratory tissues. Unlike wild type virus, Ca-DelMut causes no obvious pathological changes and does not induce elevation of proinflammatory cytokines, but still triggers a strong neutralizing antibody and T cell response in hamsters and mice. Ca-DelMut immunized hamsters challenged with wild type SARS-CoV-2 are fully protected, with little sign of virus replication in the upper or lower respiratory tract, demonstrating sterilizing immunity. Twit Text FOAVip Characterization of an attenuated SARS-CoV-2 variant with a deletion at the S1/S2 junction of the spike protein ????Nat Commun http://www.kidney.de/pget.php?&tw=1&pmid=33986286 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=33986286 #FOAvip English Wikipedia <ref>{{Cite pmid|33986286}}</ref> Characterization of an attenuated SARS-CoV-2 variant with a deletion at the S1/S2 junction of the spike protein #MMPMID33986286 Wang P; Lau SY; Deng S; Chen P; Mok BW; Zhang AJ; Lee AC; Chan KH; Tam RC; Xu H; Zhou R; Song W; Liu L; To KK; Chan JF; Chen Z; Yuen KY; Chen H Nat Commun 2021[May]; 12 (1): 2790 PMID33986286show ga SARS-CoV-2 is of zoonotic origin and contains a PRRA polybasic cleavage motif which is considered critical for efficient infection and transmission in humans. We previously reported on a panel of attenuated SARS-CoV-2 variants with deletions at the S1/S2 junction of the spike protein. Here, we characterize pathogenicity, immunogenicity, and protective ability of a further cell-adapted SARS-CoV-2 variant, Ca-DelMut, in in vitro and in vivo systems. Ca-DelMut replicates more efficiently than wild type or parental virus in Vero E6 cells, but causes no apparent disease in hamsters, despite replicating in respiratory tissues. Unlike wild type virus, Ca-DelMut causes no obvious pathological changes and does not induce elevation of proinflammatory cytokines, but still triggers a strong neutralizing antibody and T cell response in hamsters and mice. Ca-DelMut immunized hamsters challenged with wild type SARS-CoV-2 are fully protected, with little sign of virus replication in the upper or lower respiratory tract, demonstrating sterilizing immunity. |*Mutation[MESH] |Animals[MESH] |COVID-19/*diagnosis/immunology/virology[MESH] |Cell Line, Tumor[MESH] |Chlorocebus aethiops[MESH] |Cricetinae[MESH] |Cytokines/immunology/metabolism[MESH] |Female[MESH] |Host-Pathogen Interactions[MESH] |Humans[MESH] |Male[MESH] |Mesocricetus[MESH] |Mice[MESH] |Mice, Inbred BALB C[MESH] |SARS-CoV-2/*genetics/immunology/pathogenicity[MESH] |Spike Glycoprotein, Coronavirus/*genetics[MESH] |T-Lymphocytes/immunology/metabolism[MESH] |Vero Cells[MESH] |Virulence/genetics/immunology[MESH]Characterization of an attenuated SARS-CoV-2 variant with a deletion a(epmc).pdf DeepDyve Pubget Overpricing