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10.1172/jci.insight.148435 http://scihub22266oqcxt.onion/10.1172/jci.insight.148435 33986193!8262329!33986193     free     free     free Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 265.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 265.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 265.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       JCI+Insight 2021 ; 6 (9): ä Nephropedia Template TP {{tp|p=33986193|t=2021. A specific low-density neutrophil population correlates with hypercoagulation and disease severity in hospitalized COVID-19 patients |pdf=|usr=}}{{33986193}} gab.com Text A specific low-density neutrophil population correlates with hypercoagulation and disease severity in hospitalized COVID-19 patients JO: JCI Insight http://www.kidney.de/pget.php?&tw=1&pmid=33986193 #FOAvip SARS coronavirus 2 (SARS-CoV-2) is a novel viral pathogen that causes a clinical disease called coronavirus disease 2019 (COVID-19). Although most COVID-19 cases are asymptomatic or involve mild upper respiratory tract symptoms, a significant number of patients develop severe or critical disease. Patients with severe COVID-19 commonly present with viral pneumonia that may progress to life-threatening acute respiratory distress syndrome (ARDS). Patients with COVID-19 are also predisposed to venous and arterial thromboses that are associated with a poorer prognosis. The present study identified the emergence of a low-density inflammatory neutrophil (LDN) population expressing intermediate levels of CD16 (CD16Int) in patients with COVID-19. These cells demonstrated proinflammatory gene signatures, activated platelets, spontaneously formed neutrophil extracellular traps, and enhanced phagocytic capacity and cytokine production. Strikingly, CD16Int neutrophils were also the major immune cells within the bronchoalveolar lavage fluid, exhibiting increased CXCR3 but loss of CD44 and CD38 expression. The percentage of circulating CD16Int LDNs was associated with D-dimer, ferritin, and systemic IL-6 and TNF-alpha levels and changed over time with altered disease status. Our data suggest that the CD16Int LDN subset contributes to COVID-19-associated coagulopathy, systemic inflammation, and ARDS. The frequency of that LDN subset in the circulation could serve as an adjunct clinical marker to monitor disease status and progression. Twit Text FOAVip A specific low-density neutrophil population correlates with hypercoagulation and disease severity in hospitalized COVID-19 patients ????JCI Insight http://www.kidney.de/pget.php?&tw=1&pmid=33986193 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=33986193 #FOAvip English Wikipedia <ref>{{Cite pmid|33986193}}</ref> A specific low-density neutrophil population correlates with hypercoagulation and disease severity in hospitalized COVID-19 patients #MMPMID33986193 Morrissey SM; Geller AE; Hu X; Tieri D; Ding C; Klaes CK; Cooke EA; Woeste MR; Martin ZC; Chen O; Bush SE; Zhang HG; Cavallazzi R; Clifford SP; Chen J; Ghare S; Barve SS; Cai L; Kong M; Rouchka EC; McLeish KR; Uriarte SM; Watson CT; Huang J; Yan J JCI Insight 2021[May]; 6 (9): ä PMID33986193show ga SARS coronavirus 2 (SARS-CoV-2) is a novel viral pathogen that causes a clinical disease called coronavirus disease 2019 (COVID-19). Although most COVID-19 cases are asymptomatic or involve mild upper respiratory tract symptoms, a significant number of patients develop severe or critical disease. Patients with severe COVID-19 commonly present with viral pneumonia that may progress to life-threatening acute respiratory distress syndrome (ARDS). Patients with COVID-19 are also predisposed to venous and arterial thromboses that are associated with a poorer prognosis. The present study identified the emergence of a low-density inflammatory neutrophil (LDN) population expressing intermediate levels of CD16 (CD16Int) in patients with COVID-19. These cells demonstrated proinflammatory gene signatures, activated platelets, spontaneously formed neutrophil extracellular traps, and enhanced phagocytic capacity and cytokine production. Strikingly, CD16Int neutrophils were also the major immune cells within the bronchoalveolar lavage fluid, exhibiting increased CXCR3 but loss of CD44 and CD38 expression. The percentage of circulating CD16Int LDNs was associated with D-dimer, ferritin, and systemic IL-6 and TNF-alpha levels and changed over time with altered disease status. Our data suggest that the CD16Int LDN subset contributes to COVID-19-associated coagulopathy, systemic inflammation, and ARDS. The frequency of that LDN subset in the circulation could serve as an adjunct clinical marker to monitor disease status and progression. |*SARS-CoV-2[MESH] |Adult[MESH] |Aged[MESH] |Aged, 80 and over[MESH] |Biomarkers/blood[MESH] |Blood Coagulation Disorders/*blood/*etiology/immunology[MESH] |COVID-19/*blood/*complications/immunology[MESH] |Cytokines/blood[MESH] |Female[MESH] |GPI-Linked Proteins/blood[MESH] |Hospitalization[MESH] |Humans[MESH] |Inflammation Mediators/blood[MESH] |Male[MESH] |Middle Aged[MESH] |Neutrophils/classification/*immunology[MESH] |Pandemics[MESH] |Phagocytosis[MESH] |Platelet Activation[MESH] |Receptors, IgG/blood[MESH] |Respiratory Distress Syndrome/blood/etiology/immunology[MESH]A specific low-density neutrophil population correlates with hypercoag(epmc).pdf DeepDyve Pubget Overpricing