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10.1684/abc.2021.1641 http://scihub22266oqcxt.onion/10.1684/abc.2021.1641 33985935!ä!33985935 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 243.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 243.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 243.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 243.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 243.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Ann+Biol+Clin+(Paris) 2021 ; 79 (2): 168-175 Nephropedia Template TP {{tp|p=33985935|t=2021. Analyse retrospective des performances du test de detection rapide antigenique du SARS-CoV-2 compare au test de reference RT-PCR |pdf=|usr=}}{{33985935}} gab.com Text Analyse retrospective des performances du test de detection rapide antigenique du SARS-CoV-2 compare au test de reference RT-PCR JO: Ann Biol Clin (Paris) http://www.kidney.de/pget.php?&tw=1&pmid=33985935 #FOAvip BACKGROUND: Discovered in 2019 in the region of Wuhan, China, the Severe Acute Respiratory Syndrome coronavirus 2 (SARS-CoV-2) rapidly established itself as a major pathogenic agent of morbidity and mortality. France has implemented a strategy to fight this virus which relies essentially on widespread RT-PCR virological testing in order to isolate positive patients. Antigenic tests have recently been made available to help the diagnostics. We have conducted a retrospective study to determine the sensitivity of these antigenic tests, comparing them to the reference RT-PCR method. METHOD: Between December 7, 2020 and January 31, 2021, each patient we received in our laboratories for an RT-PCR test was enrolled. Out of 271,649 patients, 4,881 had been submitted to an antigenic test (TDR) in the preceding 24 hours. Comparing the data resulting from both tests, we established the sensitivity and the specificity of the antigenic tests. For our analysis we included the parameter of symptom and/or the value of Cycles threshold (Ct) in our parameters. RESULTS: The sensitivity of the TDRs compared to all the positive RT-PCR tests is 56%. We further demonstrate the correlation between the symptom duration and the reduction of the nasopharyngeal viral load. Based on this data, we have established that the sensitivity of the TDRs decreases very rapidly after symptom onset, contrary to the estimated viral load in the RT-PCR. Indeed, less the 24 hours after clinical symptom onset, the sensitivity of the TDRs decreases from 74% to 60%. By including the Ct value in our parameters, we have established that, despite a high viral load and clinical symptoms since 7 days or less, the sensitivity of the TDRs is 66%. Although, a high number of asymptomatic patients among carriers of SARS-CoV-2, we have estimated a specificity of 93% for our test. CONCLUSIONS: Performance in terms of sensitivity and specificity of the TDR, as assessed in practice, are inferior to those given by the manufacturer, which raises several questions. What is the impact of falsely negative results for patients carrying a high viral load? Are the implemented measures sufficient to prevent the epidemic? Twit Text FOAVip Analyse retrospective des performances du test de detection rapide antigenique du SARS-CoV-2 compare au test de reference RT-PCR ????Ann Biol Clin (Paris) http://www.kidney.de/pget.php?&tw=1&pmid=33985935 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=33985935 #FOAvip English Wikipedia <ref>{{Cite pmid|33985935}}</ref> Analyse retrospective des performances du test de detection rapide antigenique du SARS-CoV-2 compare au test de reference RT-PCR #MMPMID33985935 Bernard M; Cosentino G; Pieri L; Zachary P; Buser M; Kbaier L; Giannoli JM Ann Biol Clin (Paris) 2021[Apr]; 79 (2): 168-175 PMID33985935show ga BACKGROUND: Discovered in 2019 in the region of Wuhan, China, the Severe Acute Respiratory Syndrome coronavirus 2 (SARS-CoV-2) rapidly established itself as a major pathogenic agent of morbidity and mortality. France has implemented a strategy to fight this virus which relies essentially on widespread RT-PCR virological testing in order to isolate positive patients. Antigenic tests have recently been made available to help the diagnostics. We have conducted a retrospective study to determine the sensitivity of these antigenic tests, comparing them to the reference RT-PCR method. METHOD: Between December 7, 2020 and January 31, 2021, each patient we received in our laboratories for an RT-PCR test was enrolled. Out of 271,649 patients, 4,881 had been submitted to an antigenic test (TDR) in the preceding 24 hours. Comparing the data resulting from both tests, we established the sensitivity and the specificity of the antigenic tests. For our analysis we included the parameter of symptom and/or the value of Cycles threshold (Ct) in our parameters. RESULTS: The sensitivity of the TDRs compared to all the positive RT-PCR tests is 56%. We further demonstrate the correlation between the symptom duration and the reduction of the nasopharyngeal viral load. Based on this data, we have established that the sensitivity of the TDRs decreases very rapidly after symptom onset, contrary to the estimated viral load in the RT-PCR. Indeed, less the 24 hours after clinical symptom onset, the sensitivity of the TDRs decreases from 74% to 60%. By including the Ct value in our parameters, we have established that, despite a high viral load and clinical symptoms since 7 days or less, the sensitivity of the TDRs is 66%. Although, a high number of asymptomatic patients among carriers of SARS-CoV-2, we have estimated a specificity of 93% for our test. CONCLUSIONS: Performance in terms of sensitivity and specificity of the TDR, as assessed in practice, are inferior to those given by the manufacturer, which raises several questions. What is the impact of falsely negative results for patients carrying a high viral load? Are the implemented measures sufficient to prevent the epidemic? |Antigens, Viral/analysis[MESH] |COVID-19 Testing/*methods[MESH] |COVID-19/*diagnosis[MESH] |Humans[MESH] |Middle Aged[MESH] |Retrospective Studies[MESH] |Reverse Transcriptase Polymerase Chain Reaction[MESH] |SARS-CoV-2[MESH]Analyse retrospective des performances du test de detection rapide ant(epmc).pdf DeepDyve Pubget Overpricing