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10.1186/s13567-021-00943-9

http://scihub22266oqcxt.onion/10.1186/s13567-021-00943-9
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suck abstract from ncbi


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pmid33985573      Vet+Res 2021 ; 52 (1): 70
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  • Generation and evaluation of IgY-scFv based mimetics against canine parvovirus #MMPMID33985573
  • Ge S; Zhang X; Zhong F; Liu X; Zhang X
  • Vet Res 2021[May]; 52 (1): 70 PMID33985573show ga
  • Antibody mimetics may be used for various biomedical applications, especially those for which conventional antibodies are ineffective. In this study, we developed a smaller molecular chicken IgY mimetic peptide (IgY-peptide) based on the complementarity-determining regions (CDRs) of the anti-canine parvovirus (CPV) IgY-scFv prepared previously. The mimetic peptide showed no cross-reactivity with canine distemper virus (CDV) and canine coronavirus (CCV) and showed excellent protective properties for Crandell-Rees Feline Kidney (CRFK) cells against CPV. This study is the first attempt to develop a mimetic IgY-peptide and demonstrates the ease and feasibility in generating such a novel antibody-like functional molecule for biomedical purposes.
  • |Animals[MESH]
  • |Biomimetics[MESH]
  • |Cats[MESH]
  • |Cell Line[MESH]
  • |Chickens[MESH]
  • |Dogs[MESH]
  • |Feces/virology[MESH]
  • |Immunoglobulins/immunology/*metabolism[MESH]
  • |Parvovirus, Canine/*immunology[MESH]
  • |Pilot Projects[MESH]


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