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10.1016/j.ymthe.2021.05.005 http://scihub22266oqcxt.onion/10.1016/j.ymthe.2021.05.005 33984520!8110335!33984520     free     free     free Deprecated: Implicit conversion from float 229.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 229.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 229.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 229.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 229.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 263.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Mol+Ther 2021 ; 29 (8): 2424-2440 Nephropedia Template TP {{tp|p=33984520|t=2021. Plant-derived exosomal microRNAs inhibit lung inflammation induced by exosomes SARS-CoV-2 Nsp12 |pdf=|usr=}}{{33984520}} gab.com Text Plant-derived exosomal microRNAs inhibit lung inflammation induced by exosomes SARS-CoV-2 Nsp12 JO: Mol Ther http://www.kidney.de/pget.php?&tw=1&pmid=33984520 #FOAvip Lung inflammation is a hallmark of coronavirus disease 2019 (COVID-19). In this study, we show that mice develop inflamed lung tissue after being administered exosomes released from the lung epithelial cells exposed to severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) Nsp12 and Nsp13 (exosomes(Nsp12Nsp13)). Mechanistically, we show that exosomes(Nsp12Nsp13) are taken up by lung macrophages, leading to activation of nuclear factor kappaB (NF-kappaB) and the subsequent induction of an array of inflammatory cytokines. Induction of tumor necrosis factor (TNF)-alpha, interleukin (IL)-6, and IL-1beta from exosomes(Nsp12Nsp13)-activated lung macrophages contributes to inducing apoptosis in lung epithelial cells. Induction of exosomes(Nsp12Nsp13)-mediated lung inflammation was abolished with ginger exosome-like nanoparticle (GELN) microRNA (miRNA aly-miR396a-5p. The role of GELNs in inhibition of the SARS-CoV-2-induced cytopathic effect (CPE) was further demonstrated via GELN aly-miR396a-5p- and rlcv-miR-rL1-28-3p-mediated inhibition of expression of Nsp12 and spike genes, respectively. Taken together, our results reveal exosomes(Nsp12Nsp13) as potentially important contributors to the development of lung inflammation, and GELNs are a potential therapeutic agent to treat COVID-19. Twit Text FOAVip Plant-derived exosomal microRNAs inhibit lung inflammation induced by exosomes SARS-CoV-2 Nsp12 ????Mol Ther http://www.kidney.de/pget.php?&tw=1&pmid=33984520 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=33984520 #FOAvip English Wikipedia <ref>{{Cite pmid|33984520}}</ref> Plant-derived exosomal microRNAs inhibit lung inflammation induced by exosomes SARS-CoV-2 Nsp12 #MMPMID33984520 Teng Y; Xu F; Zhang X; Mu J; Sayed M; Hu X; Lei C; Sriwastva M; Kumar A; Sundaram K; Zhang L; Park JW; Chen SY; Zhang S; Yan J; Merchant ML; Zhang X; McClain CJ; Wolfe JK; Adcock RS; Chung D; Palmer KE; Zhang HG Mol Ther 2021[Aug]; 29 (8): 2424-2440 PMID33984520show ga Lung inflammation is a hallmark of coronavirus disease 2019 (COVID-19). In this study, we show that mice develop inflamed lung tissue after being administered exosomes released from the lung epithelial cells exposed to severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) Nsp12 and Nsp13 (exosomes(Nsp12Nsp13)). Mechanistically, we show that exosomes(Nsp12Nsp13) are taken up by lung macrophages, leading to activation of nuclear factor kappaB (NF-kappaB) and the subsequent induction of an array of inflammatory cytokines. Induction of tumor necrosis factor (TNF)-alpha, interleukin (IL)-6, and IL-1beta from exosomes(Nsp12Nsp13)-activated lung macrophages contributes to inducing apoptosis in lung epithelial cells. Induction of exosomes(Nsp12Nsp13)-mediated lung inflammation was abolished with ginger exosome-like nanoparticle (GELN) microRNA (miRNA aly-miR396a-5p. The role of GELNs in inhibition of the SARS-CoV-2-induced cytopathic effect (CPE) was further demonstrated via GELN aly-miR396a-5p- and rlcv-miR-rL1-28-3p-mediated inhibition of expression of Nsp12 and spike genes, respectively. Taken together, our results reveal exosomes(Nsp12Nsp13) as potentially important contributors to the development of lung inflammation, and GELNs are a potential therapeutic agent to treat COVID-19. |A549 Cells[MESH] |Animals[MESH] |COVID-19/*metabolism[MESH] |Cell Line[MESH] |Cell Line, Tumor[MESH] |Chlorocebus aethiops[MESH] |Cytokines/metabolism[MESH] |Epithelial Cells/metabolism[MESH] |Exosomes/*metabolism[MESH] |Humans[MESH] |Interleukin-6/metabolism[MESH] |Macrophages, Alveolar/metabolism[MESH] |Male[MESH] |Mice[MESH] |Mice, Inbred C57BL[MESH] |MicroRNAs/*metabolism[MESH] |NF-kappa B/metabolism[MESH] |Plants/*metabolism[MESH] |Pneumonia/*metabolism[MESH] |SARS-CoV-2/pathogenicity[MESH] |Tumor Necrosis Factor-alpha/metabolism[MESH] |U937 Cells[MESH]Plant-derived exosomal microRNAs inhibit lung inflammation induced by (epmc).pdf DeepDyve Pubget Overpricing