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10.1016/j.celrep.2021.109133 http://scihub22266oqcxt.onion/10.1016/j.celrep.2021.109133 33984267!8075848!33984267     free     free     free Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 265.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 265.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 265.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 265.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 265.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 265.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Cell+Rep 2021 ; 35 (7): 109133 Nephropedia Template TP {{tp|p=33984267|t=2021. Hepatitis C virus drugs that inhibit SARS-CoV-2 papain-like protease synergize with remdesivir to suppress viral replication in cell culture |pdf=|usr=}}{{33984267}} gab.com Text Hepatitis C virus drugs that inhibit SARS-CoV-2 papain-like protease synergize with remdesivir to suppress viral replication in cell culture JO: Cell Rep http://www.kidney.de/pget.php?&tw=1&pmid=33984267 #FOAvip Effective control of COVID-19 requires antivirals directed against SARS-CoV-2. We assessed 10 hepatitis C virus (HCV) protease-inhibitor drugs as potential SARS-CoV-2 antivirals. There is a striking structural similarity of the substrate binding clefts of SARS-CoV-2 main protease (M(pro)) and HCV NS3/4A protease. Virtual docking experiments show that these HCV drugs can potentially bind into the M(pro) substrate-binding cleft. We show that seven HCV drugs inhibit both SARS-CoV-2 M(pro) protease activity and SARS-CoV-2 virus replication in Vero and/or human cells. However, their M(pro) inhibiting activities did not correlate with their antiviral activities. This conundrum is resolved by demonstrating that four HCV protease inhibitor drugs, simeprevir, vaniprevir, paritaprevir, and grazoprevir inhibit the SARS CoV-2 papain-like protease (PL(pro)). HCV drugs that inhibit PL(pro) synergize with the viral polymerase inhibitor remdesivir to inhibit virus replication, increasing remdesivir's antiviral activity as much as 10-fold, while those that only inhibit M(pro) do not synergize with remdesivir. Twit Text FOAVip Hepatitis C virus drugs that inhibit SARS-CoV-2 papain-like protease synergize with remdesivir to suppress viral replication in cell culture ????Cell Rep http://www.kidney.de/pget.php?&tw=1&pmid=33984267 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=33984267 #FOAvip English Wikipedia <ref>{{Cite pmid|33984267}}</ref> Hepatitis C virus drugs that inhibit SARS-CoV-2 papain-like protease synergize with remdesivir to suppress viral replication in cell culture #MMPMID33984267 Bafna K; White K; Harish B; Rosales R; Ramelot TA; Acton TB; Moreno E; Kehrer T; Miorin L; Royer CA; Garcia-Sastre A; Krug RM; Montelione GT Cell Rep 2021[May]; 35 (7): 109133 PMID33984267show ga Effective control of COVID-19 requires antivirals directed against SARS-CoV-2. We assessed 10 hepatitis C virus (HCV) protease-inhibitor drugs as potential SARS-CoV-2 antivirals. There is a striking structural similarity of the substrate binding clefts of SARS-CoV-2 main protease (M(pro)) and HCV NS3/4A protease. Virtual docking experiments show that these HCV drugs can potentially bind into the M(pro) substrate-binding cleft. We show that seven HCV drugs inhibit both SARS-CoV-2 M(pro) protease activity and SARS-CoV-2 virus replication in Vero and/or human cells. However, their M(pro) inhibiting activities did not correlate with their antiviral activities. This conundrum is resolved by demonstrating that four HCV protease inhibitor drugs, simeprevir, vaniprevir, paritaprevir, and grazoprevir inhibit the SARS CoV-2 papain-like protease (PL(pro)). HCV drugs that inhibit PL(pro) synergize with the viral polymerase inhibitor remdesivir to inhibit virus replication, increasing remdesivir's antiviral activity as much as 10-fold, while those that only inhibit M(pro) do not synergize with remdesivir. |*COVID-19 Drug Treatment[MESH] |Adenosine Monophosphate/analogs & derivatives/pharmacology[MESH] |Alanine/analogs & derivatives/pharmacology[MESH] |Antiviral Agents/*pharmacology[MESH] |COVID-19/virology[MESH] |Cell Culture Techniques[MESH] |Cell Line[MESH] |Coronavirus Papain-Like Proteases/*antagonists & inhibitors/metabolism[MESH] |Drug Repositioning/methods[MESH] |Drug Synergism[MESH] |Hepacivirus/drug effects[MESH] |Hepatitis C/drug therapy[MESH] |Humans[MESH] |Molecular Docking Simulation[MESH] |Molecular Dynamics Simulation[MESH] |Protease Inhibitors/pharmacology[MESH] |SARS-CoV-2/*drug effects/*enzymology[MESH]Hepatitis C virus drugs that inhibit SARS-CoV-2 papain-like protease s(epmc).pdf DeepDyve Pubget Overpricing