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10.1093/genetics/iyab074 http://scihub22266oqcxt.onion/10.1093/genetics/iyab074 33983397!8194586!33983397     free     free     free Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Genetics 2021 ; 218 (3): ä Nephropedia Template TP {{tp|p=33983397|t=2021. Rapid detection of inter-clade recombination in SARS-CoV-2 with Bolotie |pdf=|usr=}}{{33983397}} gab.com Text Rapid detection of inter-clade recombination in SARS-CoV-2 with Bolotie JO: Genetics http://www.kidney.de/pget.php?&tw=1&pmid=33983397 #FOAvip The ability to detect recombination in pathogen genomes is crucial to the accuracy of phylogenetic analysis and consequently to forecasting the spread of infectious diseases and to developing therapeutics and public health policies. However, in case of the SARS-CoV-2, the low divergence of near-identical genomes sequenced over a short period of time makes conventional analysis infeasible. Using a novel method, we identified 225 anomalous SARS-CoV-2 genomes of likely recombinant origins out of the first 87,695 genomes to be released, several of which have persisted in the population. Bolotie is specifically designed to perform a rapid search for inter-clade recombination events over extremely large datasets, facilitating analysis of novel isolates in seconds. In cases where raw sequencing data were available, we were able to rule out the possibility that these samples represented co-infections by analyzing the underlying sequence reads. The Bolotie software and other data from our study are available at https://github.com/salzberg-lab/bolotie. Twit Text FOAVip Rapid detection of inter-clade recombination in SARS-CoV-2 with Bolotie ????Genetics http://www.kidney.de/pget.php?&tw=1&pmid=33983397 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=33983397 #FOAvip English Wikipedia <ref>{{Cite pmid|33983397}}</ref> Rapid detection of inter-clade recombination in SARS-CoV-2 with Bolotie #MMPMID33983397 Varabyou A; Pockrandt C; Salzberg SL; Pertea M Genetics 2021[Jul]; 218 (3): ä PMID33983397show ga The ability to detect recombination in pathogen genomes is crucial to the accuracy of phylogenetic analysis and consequently to forecasting the spread of infectious diseases and to developing therapeutics and public health policies. However, in case of the SARS-CoV-2, the low divergence of near-identical genomes sequenced over a short period of time makes conventional analysis infeasible. Using a novel method, we identified 225 anomalous SARS-CoV-2 genomes of likely recombinant origins out of the first 87,695 genomes to be released, several of which have persisted in the population. Bolotie is specifically designed to perform a rapid search for inter-clade recombination events over extremely large datasets, facilitating analysis of novel isolates in seconds. In cases where raw sequencing data were available, we were able to rule out the possibility that these samples represented co-infections by analyzing the underlying sequence reads. The Bolotie software and other data from our study are available at https://github.com/salzberg-lab/bolotie. |*SARS-CoV-2[MESH] |Genome, Viral[MESH] |Phylogeny[MESH] |Recombination, Genetic[MESH]Rapid detection of inter-clade recombination in SARS-CoV-2 with Boloti(epmc).pdf DeepDyve Pubget Overpricing