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10.2217/nnm-2020-0475 http://scihub22266oqcxt.onion/10.2217/nnm-2020-0475 33982600!8117723!33982600     free     free     free Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Nanomedicine+(Lond) 2021 ; 16 (14): 1187-1202 Nephropedia Template TP {{tp|p=33982600|t=2021. Aerosolized nanoliposomal carrier of remdesivir: an effective alternative for COVID-19 treatment in vitro |pdf=|usr=}}{{33982600}} gab.com Text Aerosolized nanoliposomal carrier of remdesivir: an effective alternative for COVID-19 treatment in vitro JO: Nanomedicine (Lond) http://www.kidney.de/pget.php?&tw=1&pmid=33982600 #FOAvip Aim: To formulate an aerosolized nanoliposomal carrier for remdesivir (AL-Rem) against coronavirus disease 2019. Methods: AL-Rem was prepared using modified hydration technique. Cytotoxicity in lung adenocarcinoma cells, stability and aerodynamic characteristics of developed liposomes were evaluated. Results: AL-Rem showed high encapsulation efficiency of 99.79%, with hydrodynamic diameter of 71.46 +/- 1.35 nm and surface charge of -32 mV. AL-Rem demonstrated minimal cytotoxicity in A549 cells and retained monolayer integrity of Calu-3 cells. AL-Rem showed sustained release, with complete drug release obtained within 50 h in simulated lung fluid. Long-term stability indicated >90% drug recovery at 4 degrees C. Desirable aerosol performance, with mass median aerodynamic diameter of 4.56 +/- 0.55 and fine particle fraction of 74.40 +/- 2.96%, confirmed successful nebulization of AL-Rem. Conclusion: AL-Rem represents an effective alternative for coronavirus disease 2019 treatment. Twit Text FOAVip Aerosolized nanoliposomal carrier of remdesivir: an effective alternative for COVID-19 treatment in vitro ????Nanomedicine (Lond) http://www.kidney.de/pget.php?&tw=1&pmid=33982600 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=33982600 #FOAvip English Wikipedia <ref>{{Cite pmid|33982600}}</ref> Aerosolized nanoliposomal carrier of remdesivir: an effective alternative for COVID-19 treatment in vitro #MMPMID33982600 Vartak R; Patil SM; Saraswat A; Patki M; Kunda NK; Patel K Nanomedicine (Lond) 2021[Jun]; 16 (14): 1187-1202 PMID33982600show ga Aim: To formulate an aerosolized nanoliposomal carrier for remdesivir (AL-Rem) against coronavirus disease 2019. Methods: AL-Rem was prepared using modified hydration technique. Cytotoxicity in lung adenocarcinoma cells, stability and aerodynamic characteristics of developed liposomes were evaluated. Results: AL-Rem showed high encapsulation efficiency of 99.79%, with hydrodynamic diameter of 71.46 +/- 1.35 nm and surface charge of -32 mV. AL-Rem demonstrated minimal cytotoxicity in A549 cells and retained monolayer integrity of Calu-3 cells. AL-Rem showed sustained release, with complete drug release obtained within 50 h in simulated lung fluid. Long-term stability indicated >90% drug recovery at 4 degrees C. Desirable aerosol performance, with mass median aerodynamic diameter of 4.56 +/- 0.55 and fine particle fraction of 74.40 +/- 2.96%, confirmed successful nebulization of AL-Rem. Conclusion: AL-Rem represents an effective alternative for coronavirus disease 2019 treatment. |*COVID-19 Drug Treatment[MESH] |*Drug Carriers[MESH] |A549 Cells[MESH] |Adenosine Monophosphate/administration & dosage/*analogs & derivatives[MESH] |Administration, Inhalation[MESH] |Aerosols[MESH] |Alanine/administration & dosage/*analogs & derivatives[MESH] |Delayed-Action Preparations[MESH] |Drug Liberation[MESH] |Humans[MESH] |Liposomes[MESH] |Nanoparticles[MESH]Aerosolized nanoliposomal carrier of remdesivir: an effective alternat(epmc).pdf DeepDyve Pubget Overpricing