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10.1016/j.stemcr.2021.04.001 http://scihub22266oqcxt.onion/10.1016/j.stemcr.2021.04.001 33979601!8111797!33979601     free     free     free Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Stem+Cell+Reports 2021 ; 16 (5): 1165-1181 Nephropedia Template TP {{tp|p=33979601|t=2021. Erythroid precursors and progenitors suppress adaptive immunity and get invaded by SARS-CoV-2 |pdf=|usr=}}{{33979601}} gab.com Text Erythroid precursors and progenitors suppress adaptive immunity and get invaded by SARS-CoV-2 JO: Stem Cell Reports http://www.kidney.de/pget.php?&tw=1&pmid=33979601 #FOAvip SARS-CoV-2 infection is associated with lower blood oxygen levels, even in patients without hypoxia requiring hospitalization. This discordance illustrates the need for a more unifying explanation as to whether SARS-CoV-2 directly or indirectly affects erythropoiesis. Here, we show significantly enriched CD71(+) erythroid precursors/progenitors in the blood circulation of COVID-19 patients. We found that these cells have distinctive immunosuppressive properties. In agreement, we observed a strong negative correlation between the frequency of these cells with T and B cell proportions in COVID-19 patients. The expansion of these CD71(+) erythroid precursors/progenitors was negatively correlated with the hemoglobin levels. A subpopulation of abundant erythroid cells, CD45(+) CD71(+) cells, co-express ACE2, TMPRSS2, CD147, and CD26, and these can be infected with SARS-CoV-2. In turn, pre-treatment of erythroid cells with dexamethasone significantly diminished ACE2/TMPRSS2 expression and subsequently reduced their infectivity with SARS-CoV-2. This provides a novel insight into the impact of SARS-CoV-2 on erythropoiesis and hypoxia seen in COVID-19 patients. Twit Text FOAVip Erythroid precursors and progenitors suppress adaptive immunity and get invaded by SARS-CoV-2 ????Stem Cell Reports http://www.kidney.de/pget.php?&tw=1&pmid=33979601 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=33979601 #FOAvip English Wikipedia <ref>{{Cite pmid|33979601}}</ref> Erythroid precursors and progenitors suppress adaptive immunity and get invaded by SARS-CoV-2 #MMPMID33979601 Shahbaz S; Xu L; Osman M; Sligl W; Shields J; Joyce M; Tyrrell DL; Oyegbami O; Elahi S Stem Cell Reports 2021[May]; 16 (5): 1165-1181 PMID33979601show ga SARS-CoV-2 infection is associated with lower blood oxygen levels, even in patients without hypoxia requiring hospitalization. This discordance illustrates the need for a more unifying explanation as to whether SARS-CoV-2 directly or indirectly affects erythropoiesis. Here, we show significantly enriched CD71(+) erythroid precursors/progenitors in the blood circulation of COVID-19 patients. We found that these cells have distinctive immunosuppressive properties. In agreement, we observed a strong negative correlation between the frequency of these cells with T and B cell proportions in COVID-19 patients. The expansion of these CD71(+) erythroid precursors/progenitors was negatively correlated with the hemoglobin levels. A subpopulation of abundant erythroid cells, CD45(+) CD71(+) cells, co-express ACE2, TMPRSS2, CD147, and CD26, and these can be infected with SARS-CoV-2. In turn, pre-treatment of erythroid cells with dexamethasone significantly diminished ACE2/TMPRSS2 expression and subsequently reduced their infectivity with SARS-CoV-2. This provides a novel insight into the impact of SARS-CoV-2 on erythropoiesis and hypoxia seen in COVID-19 patients. |Adaptive Immunity/*immunology[MESH] |Adolescent[MESH] |Adult[MESH] |Aged[MESH] |Aged, 80 and over[MESH] |Angiotensin-Converting Enzyme 2/metabolism[MESH] |Animals[MESH] |B-Lymphocytes/cytology/immunology[MESH] |COVID-19/immunology/*pathology[MESH] |Dexamethasone/pharmacology[MESH] |Erythroid Precursor Cells/immunology/*virology[MESH] |Erythropoiesis/*physiology[MESH] |Female[MESH] |Hemoglobins/*analysis[MESH] |Humans[MESH] |Lymphocyte Count[MESH] |Male[MESH] |Mice[MESH] |Mice, Inbred BALB C[MESH] |Middle Aged[MESH] |Oxygen/*blood[MESH] |SARS-CoV-2/immunology[MESH] |Serine Endopeptidases/metabolism[MESH] |T-Lymphocytes/cytology/immunology[MESH]Erythroid precursors and progenitors suppress adaptive immunity and ge(epmc).pdf DeepDyve Pubget Overpricing