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10.1016/j.stemcr.2021.01.016 http://scihub22266oqcxt.onion/10.1016/j.stemcr.2021.01.016 33979600!8111796!33979600     free     free     free Deprecated: Implicit conversion from float 215.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Stem+Cell+Reports 2021 ; 16 (5): 1156-1164 Nephropedia Template TP {{tp|p=33979600|t=2021. SARS-CoV-2 targets glial cells in human cortical organoids |pdf=|usr=}}{{33979600}} gab.com Text SARS-CoV-2 targets glial cells in human cortical organoids JO: Stem Cell Reports http://www.kidney.de/pget.php?&tw=1&pmid=33979600 #FOAvip Coronavirus disease 2019 (COVID-19) patients have manifested a variety of neurological complications, and there is still much to reveal regarding the neurotropism of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). Human stem cell-derived brain organoids offer a valuable in vitro approach to study the cellular effects of SARS-CoV-2 on the brain. Here we used human embryonic stem cell-derived cortical organoids to investigate whether SARS-CoV-2 could infect brain tissue in vitro and found that cortical organoids could be infected at low viral titers and within 6 h. Importantly, we show that glial cells and cells of the choroid plexus were preferentially targeted in our model, but not neurons. Interestingly, we also found expression of angiotensin-converting enzyme 2 in SARS-CoV-2 infected cells; however, viral replication and cell death involving DNA fragmentation does not occur. We believe that our model is a tractable platform to study the cellular effects of SARS-CoV-2 infection in brain tissue. Twit Text FOAVip SARS-CoV-2 targets glial cells in human cortical organoids ????Stem Cell Reports http://www.kidney.de/pget.php?&tw=1&pmid=33979600 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=33979600 #FOAvip English Wikipedia <ref>{{Cite pmid|33979600}}</ref> SARS-CoV-2 targets glial cells in human cortical organoids #MMPMID33979600 McMahon CL; Staples H; Gazi M; Carrion R; Hsieh J Stem Cell Reports 2021[May]; 16 (5): 1156-1164 PMID33979600show ga Coronavirus disease 2019 (COVID-19) patients have manifested a variety of neurological complications, and there is still much to reveal regarding the neurotropism of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). Human stem cell-derived brain organoids offer a valuable in vitro approach to study the cellular effects of SARS-CoV-2 on the brain. Here we used human embryonic stem cell-derived cortical organoids to investigate whether SARS-CoV-2 could infect brain tissue in vitro and found that cortical organoids could be infected at low viral titers and within 6 h. Importantly, we show that glial cells and cells of the choroid plexus were preferentially targeted in our model, but not neurons. Interestingly, we also found expression of angiotensin-converting enzyme 2 in SARS-CoV-2 infected cells; however, viral replication and cell death involving DNA fragmentation does not occur. We believe that our model is a tractable platform to study the cellular effects of SARS-CoV-2 infection in brain tissue. |COVID-19/*pathology[MESH] |Cells, Cultured[MESH] |Choroid Plexus/cytology/*pathology/virology[MESH] |Human Embryonic Stem Cells/*cytology[MESH] |Humans[MESH] |Neuroglia/pathology/*virology[MESH] |Neurons/virology[MESH] |Organoids/cytology/*innervation/*pathology[MESH]SARS-CoV-2 targets glial cells in human cortical organoids (epmc).pdf DeepDyve Pubget Overpricing