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10.1371/journal.pone.0251585 http://scihub22266oqcxt.onion/10.1371/journal.pone.0251585 33979391!8115845!33979391     free     free     free Warning: file_get_contents(https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&id=33979391&cmd=llinks): Failed to open stream: HTTP request failed! HTTP/1.1 429 Too Many Requests in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 215 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       PLoS+One 2021 ; 16 (5): e0251585 Nephropedia Template TP {{tp|p=33979391|t=2021. Discovery of human ACE2 variants with altered recognition by the SARS-CoV-2 spike protein |pdf=|usr=}}{{33979391}} gab.com Text Discovery of human ACE2 variants with altered recognition by the SARS-CoV-2 spike protein JO: PLoS One http://www.kidney.de/pget.php?&tw=1&pmid=33979391 #FOAvip Understanding how human ACE2 genetic variants differ in their recognition by SARS-CoV-2 can facilitate the leveraging of ACE2 as an axis for treating and preventing COVID-19. In this work, we experimentally interrogate thousands of ACE2 mutants to identify over one hundred human single-nucleotide variants (SNVs) that are likely to have altered recognition by the virus, and make the complementary discovery that ACE2 residues distant from the spike interface influence the ACE2-spike interaction. These findings illuminate new links between ACE2 sequence and spike recognition, and could find substantial utility in further fundamental research that augments epidemiological analyses and clinical trial design in the contexts of both existing strains of SARS-CoV-2 and novel variants that may arise in the future. Twit Text FOAVip Discovery of human ACE2 variants with altered recognition by the SARS-CoV-2 spike protein ????PLoS One http://www.kidney.de/pget.php?&tw=1&pmid=33979391 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=33979391 #FOAvip English Wikipedia <ref>{{Cite pmid|33979391}}</ref> Discovery of human ACE2 variants with altered recognition by the SARS-CoV-2 spike protein #MMPMID33979391 Heinzelman P; Romero PA PLoS One 2021[]; 16 (5): e0251585 PMID33979391show ga Understanding how human ACE2 genetic variants differ in their recognition by SARS-CoV-2 can facilitate the leveraging of ACE2 as an axis for treating and preventing COVID-19. In this work, we experimentally interrogate thousands of ACE2 mutants to identify over one hundred human single-nucleotide variants (SNVs) that are likely to have altered recognition by the virus, and make the complementary discovery that ACE2 residues distant from the spike interface influence the ACE2-spike interaction. These findings illuminate new links between ACE2 sequence and spike recognition, and could find substantial utility in further fundamental research that augments epidemiological analyses and clinical trial design in the contexts of both existing strains of SARS-CoV-2 and novel variants that may arise in the future. |Angiotensin-Converting Enzyme 2/*genetics/metabolism[MESH] |Binding Sites/genetics[MESH] |COVID-19/genetics/*metabolism[MESH] |Genetic Variation/genetics[MESH] |Humans[MESH] |Models, Molecular[MESH] |Peptidyl-Dipeptidase A/metabolism[MESH] |Polymorphism, Single Nucleotide/genetics[MESH] |Protein Binding/genetics[MESH] |Receptors, Virus/genetics[MESH] |SARS-CoV-2/genetics/metabolism/pathogenicity[MESH] |Spike Glycoprotein, Coronavirus/*genetics/metabolism[MESH]Discovery of human ACE2 variants with altered recognition by the SARS-(epmc).pdf DeepDyve Pubget Overpricing