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10.1126/scitranslmed.abf8654 http://scihub22266oqcxt.onion/10.1126/scitranslmed.abf8654 33979301!8158960!33979301     free     free     free Deprecated: Implicit conversion from float 235.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 235.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 235.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 235.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 235.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 269.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 269.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Sci+Transl+Med 2021 ; 13 (596): ä Nephropedia Template TP {{tp|p=33979301|t=2021. High titers and low fucosylation of early human anti-SARS-CoV-2 IgG promote inflammation by alveolar macrophages |pdf=|usr=}}{{33979301}} gab.com Text High titers and low fucosylation of early human anti-SARS-CoV-2 IgG promote inflammation by alveolar macrophages JO: Sci Transl Med http://www.kidney.de/pget.php?&tw=1&pmid=33979301 #FOAvip Patients diagnosed with coronavirus disease 2019 (COVID-19) become critically ill primarily around the time of activation of the adaptive immune response. Here, we provide evidence that antibodies play a role in the worsening of disease at the time of seroconversion. We show that early-phase severe acute respiratory distress syndrome coronavirus 2 (SARS-CoV-2) spike protein-specific immunoglobulin G (IgG) in serum of critically ill COVID-19 patients induces excessive inflammatory responses by human alveolar macrophages. We identified that this excessive inflammatory response is dependent on two antibody features that are specific for patients with severe COVID-19. First, inflammation is driven by high titers of anti-spike IgG, a hallmark of severe disease. Second, we found that anti-spike IgG from patients with severe COVID-19 is intrinsically more proinflammatory because of different glycosylation, particularly low fucosylation, of the antibody Fc tail. Low fucosylation of anti-spike IgG was normalized in a few weeks after initial infection with SARS-CoV-2, indicating that the increased antibody-dependent inflammation mainly occurs at the time of seroconversion. We identified Fcgamma receptor (FcgammaR) IIa and FcgammaRIII as the two primary IgG receptors that are responsible for the induction of key COVID-19-associated cytokines such as interleukin-6 and tumor necrosis factor. In addition, we show that anti-spike IgG-activated human macrophages can subsequently break pulmonary endothelial barrier integrity and induce microvascular thrombosis in vitro. Last, we demonstrate that the inflammatory response induced by anti-spike IgG can be specifically counteracted by fostamatinib, an FDA- and EMA-approved therapeutic small-molecule inhibitor of Syk kinase. Twit Text FOAVip High titers and low fucosylation of early human anti-SARS-CoV-2 IgG promote inflammation by alveolar macrophages ????Sci Transl Med http://www.kidney.de/pget.php?&tw=1&pmid=33979301 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=33979301 #FOAvip English Wikipedia <ref>{{Cite pmid|33979301}}</ref> High titers and low fucosylation of early human anti-SARS-CoV-2 IgG promote inflammation by alveolar macrophages #MMPMID33979301 Hoepel W; Chen HJ; Geyer CE; Allahverdiyeva S; Manz XD; de Taeye SW; Aman J; Mes L; Steenhuis M; Griffith GR; Bonta PI; Brouwer PJM; Caniels TG; van der Straten K; Golebski K; Jonkers RE; Larsen MD; Linty F; Nouta J; van Roomen CPAA; van Baarle FEHP; van Drunen CM; Wolbink G; Vlaar APJ; de Bree GJ; Sanders RW; Willemsen L; Neele AE; van de Beek D; Rispens T; Wuhrer M; Bogaard HJ; van Gils MJ; Vidarsson G; de Winther M; den Dunnen J Sci Transl Med 2021[Jun]; 13 (596): ä PMID33979301show ga Patients diagnosed with coronavirus disease 2019 (COVID-19) become critically ill primarily around the time of activation of the adaptive immune response. Here, we provide evidence that antibodies play a role in the worsening of disease at the time of seroconversion. We show that early-phase severe acute respiratory distress syndrome coronavirus 2 (SARS-CoV-2) spike protein-specific immunoglobulin G (IgG) in serum of critically ill COVID-19 patients induces excessive inflammatory responses by human alveolar macrophages. We identified that this excessive inflammatory response is dependent on two antibody features that are specific for patients with severe COVID-19. First, inflammation is driven by high titers of anti-spike IgG, a hallmark of severe disease. Second, we found that anti-spike IgG from patients with severe COVID-19 is intrinsically more proinflammatory because of different glycosylation, particularly low fucosylation, of the antibody Fc tail. Low fucosylation of anti-spike IgG was normalized in a few weeks after initial infection with SARS-CoV-2, indicating that the increased antibody-dependent inflammation mainly occurs at the time of seroconversion. We identified Fcgamma receptor (FcgammaR) IIa and FcgammaRIII as the two primary IgG receptors that are responsible for the induction of key COVID-19-associated cytokines such as interleukin-6 and tumor necrosis factor. In addition, we show that anti-spike IgG-activated human macrophages can subsequently break pulmonary endothelial barrier integrity and induce microvascular thrombosis in vitro. Last, we demonstrate that the inflammatory response induced by anti-spike IgG can be specifically counteracted by fostamatinib, an FDA- and EMA-approved therapeutic small-molecule inhibitor of Syk kinase. |Antibodies, Viral/*chemistry[MESH] |COVID-19/*immunology[MESH] |Glycosylation[MESH] |Humans[MESH] |Immunoglobulin G/*chemistry[MESH] |Inflammation[MESH] |Macrophages, Alveolar/*immunology[MESH] |SARS-CoV-2[MESH]High titers and low fucosylation of early human anti-SARS-CoV-2 IgG pr(epmc).pdf DeepDyve Pubget Overpricing