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10.1080/22221751.2021.1929504 http://scihub22266oqcxt.onion/10.1080/22221751.2021.1929504 33977858!8168736!33977858     free     free     free Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Emerg+Microbes+Infect 2021 ; 10 (1): 994-997 Nephropedia Template TP {{tp|p=33977858|t=2021. A novel diagnostic test to screen SARS-CoV-2 variants containing E484K and N501Y mutations |pdf=|usr=}}{{33977858}} gab.com Text A novel diagnostic test to screen SARS-CoV-2 variants containing E484K and N501Y mutations JO: Emerg Microbes Infect http://www.kidney.de/pget.php?&tw=1&pmid=33977858 #FOAvip Spike protein mutations E484K and N501Y carried by SARS-CoV-2 variants have been associated with concerning changes of the virus, including resistance to neutralizing antibodies and increased transmissibility. While the concerning variants are fast spreading in various geographical areas, identification and monitoring of these variants are lagging far behind, due in large part to the slow speed and insufficient capacity of viral sequencing. In response to the unmet need for a fast and efficient screening tool, we developed a single-tube duplex molecular assay for rapid and simultaneous identification of E484K and N501Y mutations from nasopharyngeal swab (NS) samples within 2.5 h from sample preparation to report. Using this tool, we screened a total of 1135 clinical NS samples collected from COVID patients at 8 hospitals within the Hackensack Meridian Health network in New Jersey between late December 2020 and March 2021. Our data revealed dramatic increases in the frequencies of both E484K and N501Y over time, underscoring the need for continuous epidemiological monitoring. Twit Text FOAVip A novel diagnostic test to screen SARS-CoV-2 variants containing E484K and N501Y mutations ????Emerg Microbes Infect http://www.kidney.de/pget.php?&tw=1&pmid=33977858 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=33977858 #FOAvip English Wikipedia <ref>{{Cite pmid|33977858}}</ref> A novel diagnostic test to screen SARS-CoV-2 variants containing E484K and N501Y mutations #MMPMID33977858 Zhao Y; Lee A; Composto K; Cunningham MH; Mediavilla JR; Fennessey S; Corvelo A; Chow KF; Zody M; Chen L; Kreiswirth BN; Perlin DS Emerg Microbes Infect 2021[Dec]; 10 (1): 994-997 PMID33977858show ga Spike protein mutations E484K and N501Y carried by SARS-CoV-2 variants have been associated with concerning changes of the virus, including resistance to neutralizing antibodies and increased transmissibility. While the concerning variants are fast spreading in various geographical areas, identification and monitoring of these variants are lagging far behind, due in large part to the slow speed and insufficient capacity of viral sequencing. In response to the unmet need for a fast and efficient screening tool, we developed a single-tube duplex molecular assay for rapid and simultaneous identification of E484K and N501Y mutations from nasopharyngeal swab (NS) samples within 2.5 h from sample preparation to report. Using this tool, we screened a total of 1135 clinical NS samples collected from COVID patients at 8 hospitals within the Hackensack Meridian Health network in New Jersey between late December 2020 and March 2021. Our data revealed dramatic increases in the frequencies of both E484K and N501Y over time, underscoring the need for continuous epidemiological monitoring. |*Mutation[MESH] |Antibodies, Neutralizing/immunology[MESH] |Antibodies, Viral/immunology[MESH] |COVID-19/epidemiology/*virology[MESH] |Genotype[MESH] |Humans[MESH] |Nasopharynx/virology[MESH] |New Jersey/epidemiology[MESH] |RNA, Viral/chemistry/genetics[MESH] |SARS-CoV-2/*genetics[MESH] |Sensitivity and Specificity[MESH] |Spike Glycoprotein, Coronavirus/*genetics[MESH]A novel diagnostic test to screen SARS-CoV-2 variants containing E484K(epmc).pdf DeepDyve Pubget Overpricing