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10.1093/cid/ciab319

http://scihub22266oqcxt.onion/10.1093/cid/ciab319
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suck abstract from ncbi


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pmid33977301      Clin+Infect+Dis 2021 ; 73 (Suppl 1): S32-S37
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  • Adults Hospitalized With Coronavirus Disease 2019 (COVID-19)-United States, March-June and October-December 2020: Implications for the Potential Effects of COVID-19 Tier-1 Vaccination on Future Hospitalizations and Outcomes #MMPMID33977301
  • Sami S; Tenforde MW; Talbot HK; Lindsell CJ; Steingrub JS; Shapiro NI; Ginde AA; Douin DJ; Prekker ME; Erickson HL; Brown SM; Peltan ID; Gong MN; Khan A; Exline MC; Files DC; Gibbs KW; Rice TW; Casey JD; Grijalva CG; Stubblefield WB; Womack KN; Hager DN; Qadir N; Chang SY; Henning DJ; Wilson JG; Self WH; Patel MM
  • Clin Infect Dis 2021[Jul]; 73 (Suppl 1): S32-S37 PMID33977301show ga
  • BACKGROUND: Because of the increased risk for severe coronavirus disease 2019 (COVID-19), the Advisory Committee on Immunization Practices (ACIP) initially prioritized COVID-19 vaccination for persons in long-term care facilities (LTCF), persons aged >/=65 years, and persons aged 16-64 years with high-risk medical conditions when there is limited vaccine supply. We compared characteristics and severe outcomes of hospitalized patients with COVID-19 in the United States between early and later in the pandemic categorized by groups at higher risk of severe COVID-19. METHODS: Observational study of sampled patients aged >/=18 years who tested positive for severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) and admitted to one of 14 academic hospitals in the United States during March-June and October-December 2020. Demographic and clinical information were gathered from electronic health record data. RESULTS: Among 647 patients, 91% met >/=1 of the following risk factors for severe COVID-19 [91% March-June (n = 434); 90% October-December (n = 213)]; 19% were LTCF residents, 45% were aged >/=65-years, and 84% had >/=1 high-risk condition. The proportion of patients who resided in a LTCF declined significantly (25% vs 6%) from early to later pandemic periods. Compared with patients at lower risk for severe COVID-19, in-hospital mortality was higher among patients at high risk for severe COVID-19 (20% vs 7%); these differences were consistently observed between March-June and October-December. CONCLUSIONS: Most adults hospitalized with COVID-19 were those recommended to be prioritized for vaccination based on risk for developing severe COVID-19. These findings highlight the continued urgency to vaccinate patients at high risk for severe COVID-19 and monitor vaccination impact on hospitalizations and outcomes.
  • |*COVID-19[MESH]
  • |Adolescent[MESH]
  • |Adult[MESH]
  • |COVID-19 Vaccines[MESH]
  • |Hospitalization[MESH]
  • |Humans[MESH]
  • |SARS-CoV-2[MESH]
  • |United States/epidemiology[MESH]


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