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10.1016/j.xcrm.2021.100291 http://scihub22266oqcxt.onion/10.1016/j.xcrm.2021.100291 33977279!8101789!33977279     free     free     free Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 267.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 267.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Cell+Rep+Med 2021 ; 2 (6): 100291 Nephropedia Template TP {{tp|p=33977279|t=2021. Comparative immune profiling of acute respiratory distress syndrome patients with or without SARS-CoV-2 infection |pdf=|usr=}}{{33977279}} gab.com Text Comparative immune profiling of acute respiratory distress syndrome patients with or without SARS-CoV-2 infection JO: Cell Rep Med http://www.kidney.de/pget.php?&tw=1&pmid=33977279 #FOAvip Acute respiratory distress syndrome (ARDS) is the main complication of coronavirus disease 2019 (COVID-19), requiring admission to the intensive care unit (ICU). Despite extensive immune profiling of COVID-19 patients, to what extent COVID-19-associated ARDS differs from other causes of ARDS remains unknown. To address this question, here, we build 3 cohorts of patients categorized in COVID-19(-)ARDS(+), COVID-19(+)ARDS(+), and COVID-19(+)ARDS(-), and compare, by high-dimensional mass cytometry, their immune landscape. A cell signature associating S100A9/calprotectin-producing CD169(+) monocytes, plasmablasts, and Th1 cells is found in COVID-19(+)ARDS(+), unlike COVID-19(-)ARDS(+) patients. Moreover, this signature is essentially shared with COVID-19(+)ARDS(-) patients, suggesting that severe COVID-19 patients, whether or not they experience ARDS, display similar immune profiles. We show an increase in CD14(+)HLA-DR(low) and CD14(low)CD16(+) monocytes correlating to the occurrence of adverse events during the ICU stay. We demonstrate that COVID-19-associated ARDS displays a specific immune profile and may benefit from personalized therapy in addition to standard ARDS management. Twit Text FOAVip Comparative immune profiling of acute respiratory distress syndrome patients with or without SARS-CoV-2 infection ????Cell Rep Med http://www.kidney.de/pget.php?&tw=1&pmid=33977279 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=33977279 #FOAvip English Wikipedia <ref>{{Cite pmid|33977279}}</ref> Comparative immune profiling of acute respiratory distress syndrome patients with or without SARS-CoV-2 infection #MMPMID33977279 Roussel M; Ferrant J; Reizine F; Le Gallou S; Dulong J; Carl S; Lesouhaitier M; Gregoire M; Bescher N; Verdy C; Latour M; Bezier I; Cornic M; Vinit A; Monvoisin C; Sawitzki B; Leonard S; Paul S; Feuillard J; Jeannet R; Daix T; Tiwari VK; Tadie JM; Cogne M; Tarte K Cell Rep Med 2021[Jun]; 2 (6): 100291 PMID33977279show ga Acute respiratory distress syndrome (ARDS) is the main complication of coronavirus disease 2019 (COVID-19), requiring admission to the intensive care unit (ICU). Despite extensive immune profiling of COVID-19 patients, to what extent COVID-19-associated ARDS differs from other causes of ARDS remains unknown. To address this question, here, we build 3 cohorts of patients categorized in COVID-19(-)ARDS(+), COVID-19(+)ARDS(+), and COVID-19(+)ARDS(-), and compare, by high-dimensional mass cytometry, their immune landscape. A cell signature associating S100A9/calprotectin-producing CD169(+) monocytes, plasmablasts, and Th1 cells is found in COVID-19(+)ARDS(+), unlike COVID-19(-)ARDS(+) patients. Moreover, this signature is essentially shared with COVID-19(+)ARDS(-) patients, suggesting that severe COVID-19 patients, whether or not they experience ARDS, display similar immune profiles. We show an increase in CD14(+)HLA-DR(low) and CD14(low)CD16(+) monocytes correlating to the occurrence of adverse events during the ICU stay. We demonstrate that COVID-19-associated ARDS displays a specific immune profile and may benefit from personalized therapy in addition to standard ARDS management. |Aged[MESH] |COVID-19/complications/*pathology/virology[MESH] |Cohort Studies[MESH] |Evolution, Molecular[MESH] |Female[MESH] |HLA-DR Antigens/metabolism[MESH] |Humans[MESH] |Intensive Care Units[MESH] |Leukocytes, Mononuclear/cytology/immunology/*metabolism[MESH] |Lipopolysaccharide Receptors/metabolism[MESH] |Machine Learning[MESH] |Male[MESH] |Middle Aged[MESH] |Monocytes/cytology/immunology/metabolism[MESH] |Respiratory Distress Syndrome/etiology/*immunology/pathology[MESH] |SARS-CoV-2/isolation & purification[MESH] |Sialic Acid Binding Ig-like Lectin 1/metabolism[MESH]Comparative immune profiling of acute respiratory distress syndrome pa(epmc).pdf DeepDyve Pubget Overpricing