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10.1038/s42003-021-02064-7 http://scihub22266oqcxt.onion/10.1038/s42003-021-02064-7 33976375!8113447!33976375     free     free     free Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Commun+Biol 2021 ; 4 (1): 557 Nephropedia Template TP {{tp|p=33976375|t=2021. Dengue virus-free defective interfering particles have potent and broad anti-dengue virus activity |pdf=|usr=}}{{33976375}} gab.com Text Dengue virus-free defective interfering particles have potent and broad anti-dengue virus activity JO: Commun Biol http://www.kidney.de/pget.php?&tw=1&pmid=33976375 #FOAvip Dengue virus (DENV) is spread from human to human through the bite of the female Aedes aegypti mosquito and leads to about 100 million clinical infections yearly. Treatment options and vaccine availability for DENV are limited. Defective interfering particles (DIPs) are considered a promising antiviral approach but infectious virus contamination has limited their development. Here, a DENV-derived DIP production cell line was developed that continuously produced DENV-free DIPs. The DIPs contained and could deliver to cells a DENV serotype 2 subgenomic defective-interfering RNA, which was originally discovered in DENV infected patients. The DIPs released into cell culture supernatant were purified and could potently inhibit replication of all DENV serotypes in cells. Antiviral therapeutics are limited for many viral infection. The DIP system described could be re-purposed to make antiviral DIPs for many other RNA viruses such as SARS-CoV-2, yellow fever, West Nile and Zika viruses. Twit Text FOAVip Dengue virus-free defective interfering particles have potent and broad anti-dengue virus activity ????Commun Biol http://www.kidney.de/pget.php?&tw=1&pmid=33976375 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=33976375 #FOAvip English Wikipedia <ref>{{Cite pmid|33976375}}</ref> Dengue virus-free defective interfering particles have potent and broad anti-dengue virus activity #MMPMID33976375 Li D; Lin MH; Rawle DJ; Jin H; Wu Z; Wang L; Lor M; Hussain M; Aaskov J; Harrich D Commun Biol 2021[May]; 4 (1): 557 PMID33976375show ga Dengue virus (DENV) is spread from human to human through the bite of the female Aedes aegypti mosquito and leads to about 100 million clinical infections yearly. Treatment options and vaccine availability for DENV are limited. Defective interfering particles (DIPs) are considered a promising antiviral approach but infectious virus contamination has limited their development. Here, a DENV-derived DIP production cell line was developed that continuously produced DENV-free DIPs. The DIPs contained and could deliver to cells a DENV serotype 2 subgenomic defective-interfering RNA, which was originally discovered in DENV infected patients. The DIPs released into cell culture supernatant were purified and could potently inhibit replication of all DENV serotypes in cells. Antiviral therapeutics are limited for many viral infection. The DIP system described could be re-purposed to make antiviral DIPs for many other RNA viruses such as SARS-CoV-2, yellow fever, West Nile and Zika viruses. |*Defective Viruses/genetics/metabolism[MESH] |*Virus Replication[MESH] |Animals[MESH] |Cell Line, Tumor[MESH] |Chlorocebus aethiops[MESH] |Dengue Vaccines/*therapeutic use[MESH] |Dengue Virus/genetics/*growth & development/metabolism[MESH] |Dengue/*prevention & control/virology[MESH] |Genes, Reporter[MESH] |HEK293 Cells[MESH] |Host-Pathogen Interactions[MESH] |Humans[MESH] |Luminescent Proteins/biosynthesis/genetics[MESH] |RNA, Viral/biosynthesis/genetics[MESH] |Vero Cells[MESH]Dengue virus-free defective interfering particles have potent and broa(epmc).pdf DeepDyve Pubget Overpricing