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10.1098/rsif.2020.0803 http://scihub22266oqcxt.onion/10.1098/rsif.2020.0803 33975462!8113910!33975462     free     free     free Warning: file_get_contents(https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&id=33975462&cmd=llinks): Failed to open stream: HTTP request failed! 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A simple criterion to design optimal non-pharmaceutical interventions for mitigating epidemic outbreaks |pdf=|usr=}}{{33975462}} gab.com Text A simple criterion to design optimal non-pharmaceutical interventions for mitigating epidemic outbreaks JO: J R Soc Interface http://www.kidney.de/pget.php?&tw=1&pmid=33975462 #FOAvip For mitigating the COVID-19 pandemic, much emphasis is made on implementing non-pharmaceutical interventions to keep the reproduction number below one. However, using that objective ignores that some of these interventions, like bans of public events or lockdowns, must be transitory and as short as possible because of their significant economic and societal costs. Here, we derive a simple and mathematically rigorous criterion for designing optimal transitory non-pharmaceutical interventions for mitigating epidemic outbreaks. We find that reducing the reproduction number below one is sufficient but not necessary. Instead, our criterion prescribes the required reduction in the reproduction number according to the desired maximum of disease prevalence and the maximum decrease of disease transmission that the interventions can achieve. We study the implications of our theoretical results for designing non-pharmaceutical interventions in 16 cities and regions during the COVID-19 pandemic. In particular, we estimate the minimal reduction of each region's contact rate necessary to control the epidemic optimally. Our results contribute to establishing a rigorous methodology to design optimal non-pharmaceutical intervention policies for mitigating epidemic outbreaks. Twit Text FOAVip A simple criterion to design optimal non-pharmaceutical interventions for mitigating epidemic outbreaks ????J R Soc Interface http://www.kidney.de/pget.php?&tw=1&pmid=33975462 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=33975462 #FOAvip English Wikipedia <ref>{{Cite pmid|33975462}}</ref> A simple criterion to design optimal non-pharmaceutical interventions for mitigating epidemic outbreaks #MMPMID33975462 Angulo MT; Castanos F; Moreno-Morton R; Velasco-Hernandez JX; Moreno JA J R Soc Interface 2021[May]; 18 (178): 20200803 PMID33975462show ga For mitigating the COVID-19 pandemic, much emphasis is made on implementing non-pharmaceutical interventions to keep the reproduction number below one. However, using that objective ignores that some of these interventions, like bans of public events or lockdowns, must be transitory and as short as possible because of their significant economic and societal costs. Here, we derive a simple and mathematically rigorous criterion for designing optimal transitory non-pharmaceutical interventions for mitigating epidemic outbreaks. We find that reducing the reproduction number below one is sufficient but not necessary. Instead, our criterion prescribes the required reduction in the reproduction number according to the desired maximum of disease prevalence and the maximum decrease of disease transmission that the interventions can achieve. We study the implications of our theoretical results for designing non-pharmaceutical interventions in 16 cities and regions during the COVID-19 pandemic. In particular, we estimate the minimal reduction of each region's contact rate necessary to control the epidemic optimally. Our results contribute to establishing a rigorous methodology to design optimal non-pharmaceutical intervention policies for mitigating epidemic outbreaks. |*COVID-19[MESH] |*Pandemics[MESH] |Communicable Disease Control[MESH] |Disease Outbreaks/prevention & control[MESH] |Humans[MESH]A simple criterion to design optimal non-pharmaceutical interventions (epmc).pdf DeepDyve Pubget Overpricing