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10.1016/j.cell.2021.04.033 http://scihub22266oqcxt.onion/10.1016/j.cell.2021.04.033 33974910!8064868!33974910     free     free     free Deprecated: Implicit conversion from float 227.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 227.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 227.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 227.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 227.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Cell 2021 ; 184 (12): 3192-3204.e16 Nephropedia Template TP {{tp|p=33974910|t=2021. Structural insight into SARS-CoV-2 neutralizing antibodies and modulation of syncytia |pdf=|usr=}}{{33974910}} gab.com Text Structural insight into SARS-CoV-2 neutralizing antibodies and modulation of syncytia JO: Cell http://www.kidney.de/pget.php?&tw=1&pmid=33974910 #FOAvip Infection with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is initiated by binding of the viral Spike protein to host receptor angiotensin-converting enzyme 2 (ACE2), followed by fusion of viral and host membranes. Although antibodies that block this interaction are in emergency use as early coronavirus disease 2019 (COVID-19) therapies, the precise determinants of neutralization potency remain unknown. We discovered a series of antibodies that potently block ACE2 binding but exhibit divergent neutralization efficacy against the live virus. Strikingly, these neutralizing antibodies can inhibit or enhance Spike-mediated membrane fusion and formation of syncytia, which are associated with chronic tissue damage in individuals with COVID-19. As revealed by cryoelectron microscopy, multiple structures of Spike-antibody complexes have distinct binding modes that not only block ACE2 binding but also alter the Spike protein conformational cycle triggered by ACE2 binding. We show that stabilization of different Spike conformations leads to modulation of Spike-mediated membrane fusion with profound implications for COVID-19 pathology and immunity. Twit Text FOAVip Structural insight into SARS-CoV-2 neutralizing antibodies and modulation of syncytia ????Cell http://www.kidney.de/pget.php?&tw=1&pmid=33974910 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=33974910 #FOAvip English Wikipedia <ref>{{Cite pmid|33974910}}</ref> Structural insight into SARS-CoV-2 neutralizing antibodies and modulation of syncytia #MMPMID33974910 Asarnow D; Wang B; Lee WH; Hu Y; Huang CW; Faust B; Ng PML; Ngoh EZX; Bohn M; Bulkley D; Pizzorno A; Ary B; Tan HC; Lee CY; Minhat RA; Terrier O; Soh MK; Teo FJ; Yeap YYC; Seah SGK; Chan CEZ; Connelly E; Young NJ; Maurer-Stroh S; Renia L; Hanson BJ; Rosa-Calatrava M; Manglik A; Cheng Y; Craik CS; Wang CI Cell 2021[Jun]; 184 (12): 3192-3204.e16 PMID33974910show ga Infection with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is initiated by binding of the viral Spike protein to host receptor angiotensin-converting enzyme 2 (ACE2), followed by fusion of viral and host membranes. Although antibodies that block this interaction are in emergency use as early coronavirus disease 2019 (COVID-19) therapies, the precise determinants of neutralization potency remain unknown. We discovered a series of antibodies that potently block ACE2 binding but exhibit divergent neutralization efficacy against the live virus. Strikingly, these neutralizing antibodies can inhibit or enhance Spike-mediated membrane fusion and formation of syncytia, which are associated with chronic tissue damage in individuals with COVID-19. As revealed by cryoelectron microscopy, multiple structures of Spike-antibody complexes have distinct binding modes that not only block ACE2 binding but also alter the Spike protein conformational cycle triggered by ACE2 binding. We show that stabilization of different Spike conformations leads to modulation of Spike-mediated membrane fusion with profound implications for COVID-19 pathology and immunity. |Angiotensin-Converting Enzyme 2/chemistry/genetics/immunology/metabolism[MESH] |Animals[MESH] |Antibodies, Neutralizing/*chemistry/immunology/metabolism[MESH] |Antigen-Antibody Complex/chemistry/metabolism[MESH] |Binding Sites[MESH] |CHO Cells[MESH] |COVID-19/pathology/virology[MESH] |Cricetinae[MESH] |Cricetulus[MESH] |Cryoelectron Microscopy[MESH] |Giant Cells/cytology/*metabolism[MESH] |Humans[MESH] |Membrane Fusion[MESH] |Peptide Library[MESH] |Protein Binding[MESH] |Protein Domains[MESH] |Protein Structure, Quaternary[MESH] |SARS-CoV-2/isolation & purification/metabolism[MESH]Structural insight into SARS-CoV-2 neutralizing antibodies and modulat(epmc).pdf DeepDyve Pubget Overpricing