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10.1016/j.cbi.2021.109501

http://scihub22266oqcxt.onion/10.1016/j.cbi.2021.109501
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33974898!8106523!33974898
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suck abstract from ncbi


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pmid33974898      Chem+Biol+Interact 2021 ; 344 (ä): 109501
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  • Elucidating of oxidative distress in COVID-19 and methods of its prevention #MMPMID33974898
  • Barciszewska AM
  • Chem Biol Interact 2021[Aug]; 344 (ä): 109501 PMID33974898show ga
  • The pandemic of SARS-CoV-2 stimulates significant efforts and approaches to understand its global spread. Although the recent introduction of the vaccine is a crucial prophylactic step, the effective treatment for SARS-CoV-2 is still undiscovered. An in-depth analysis of symptoms and clinical parameters, as well as molecular changes, is necessary to comprehend COVID-19 and propose a remedy for affected people to fight that disease. The analysis of available clinical data and SARS-CoV-2 infection markers underlined the main pathogenic process in COVID-19 is cytokine storm and inflammation. That led us to suggest that the most important pathogenic feature of SARS-CoV-2 leading to COVID-19 is oxidative stress and cellular damage stimulated by iron, a source of Fenton reaction and its product hydroxyl radical (*OH), the most reactive ROS with t(1/2)-10(-9)s. Therefore we suggest some scavenging agents are a reasonable choice for overcoming its toxic effect and can be regarded as a treatment for the disease on the molecular level.
  • |COVID-19/*metabolism/*prevention & control[MESH]
  • |Cytokine Release Syndrome/metabolism[MESH]
  • |Cytokines/metabolism[MESH]
  • |Humans[MESH]
  • |Hydroxyl Radical/metabolism[MESH]
  • |Inflammation/metabolism[MESH]
  • |Iron/metabolism[MESH]
  • |Oxidation-Reduction[MESH]
  • |Oxidative Stress/*physiology[MESH]
  • |Pandemics/*prevention & control[MESH]
  • |Reactive Oxygen Species/metabolism[MESH]


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