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10.1007/978-3-030-63761-3_9

http://scihub22266oqcxt.onion/10.1007/978-3-030-63761-3_9
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33973177!ä!33973177

suck abstract from ncbi


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pmid33973177      Adv+Exp+Med+Biol 2021 ; 1318 (ä): 149-167
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  • Potential Antiviral Immune Response Against COVID-19: Lessons Learned from SARS-CoV #MMPMID33973177
  • Akbarpour M; Sharifi L; Safdarian AR; Farhangnia P; Borjkhani M; Rezaei N
  • Adv Exp Med Biol 2021[]; 1318 (ä): 149-167 PMID33973177show ga
  • Virus and host innate immune system interaction plays a significant role in forming the outcome of viral diseases. Host innate immunity initially recognizes the viral invasion and induces a rapid inflammatory response, and this recognition activates signaling cascades that trigger the release of antiviral mediators. This chapter aims to explore the mechanisms by which newly emerged coronavirus called severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) activates the host immune system. Since SARS-CoV-2 shares similarities with SARS-CoV that caused the epidemic of SARS in 2003, the pathogenesis of both viruses could be at least very similar. For this, this chapter provides a synthesis of literature concerning antiviral immunity in SARS-CoV and SARS-CoV-2. It includes the presentation of epitopes linked to SARS-CoV-2 as well as the ability of SARS-CoV-2 to cause proteolytic activation and interact with angiotensin-converting enzyme 2 (ACE2) via molecular mimicry. This chapter characterizes various mechanisms that this virus may engage in escaping the host immunity, ended by a discussion of humoral immune responses against SARS-CoV-2.
  • |*COVID-19[MESH]
  • |*Epidemics[MESH]
  • |Antiviral Agents/therapeutic use[MESH]
  • |Humans[MESH]
  • |Immunity, Innate[MESH]
  • |Peptidyl-Dipeptidase A[MESH]


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