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10.1007/s00415-021-10595-6 http://scihub22266oqcxt.onion/10.1007/s00415-021-10595-6 33973106!8108733!33973106     free     free     free Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       J+Neurol 2021 ; 268 (12): 4436-4442 Nephropedia Template TP {{tp|p=33973106|t=2021. Blood neurofilament light chain and total tau levels at admission predict death in COVID-19 patients |pdf=|usr=}}{{33973106}} gab.com Text Blood neurofilament light chain and total tau levels at admission predict death in COVID-19 patients JO: J Neurol http://www.kidney.de/pget.php?&tw=1&pmid=33973106 #FOAvip BACKGROUND AND AIMS: Patients infected with SARS-CoV-2 range from asymptomatic, to mild, moderate or severe disease evolution including fatal outcome. Thus, early predictors of clinical outcome are highly needed. We investigated markers of neural tissue damage as a possible early sign of multisystem involvement to assess their clinical prognostic value on survival or transfer to intensive care unit (ICU). METHODS: We collected blood from 104 patients infected with SARS-CoV-2 the day of admission to the emergency room and measured blood neurofilament light chair (NfL), glial fibrillary acidic protein (GFAP), ubiquitin carboxy-terminal hydrolase L1 (UCH-L1), and total tau protein levels. RESULTS: We found that NfL, GFAP, and tau were significantly increased in patients with fatal outcome, while NfL and UCH-L1 in those needing ICU transfer. ROC and Kaplan-Meier curves indicated that total tau levels at admission accurately predict mortality. CONCLUSIONS: Blood neural markers may provide additional prognostic value to conventional biomarkers used to predict COVID-19 outcome. Twit Text FOAVip Blood neurofilament light chain and total tau levels at admission predict death in COVID-19 patients ????J Neurol http://www.kidney.de/pget.php?&tw=1&pmid=33973106 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=33973106 #FOAvip English Wikipedia <ref>{{Cite pmid|33973106}}</ref> Blood neurofilament light chain and total tau levels at admission predict death in COVID-19 patients #MMPMID33973106 De Lorenzo R; Lore NI; Finardi A; Mandelli A; Cirillo DM; Tresoldi C; Benedetti F; Ciceri F; Rovere-Querini P; Comi G; Filippi M; Manfredi AA; Furlan R J Neurol 2021[Dec]; 268 (12): 4436-4442 PMID33973106show ga BACKGROUND AND AIMS: Patients infected with SARS-CoV-2 range from asymptomatic, to mild, moderate or severe disease evolution including fatal outcome. Thus, early predictors of clinical outcome are highly needed. We investigated markers of neural tissue damage as a possible early sign of multisystem involvement to assess their clinical prognostic value on survival or transfer to intensive care unit (ICU). METHODS: We collected blood from 104 patients infected with SARS-CoV-2 the day of admission to the emergency room and measured blood neurofilament light chair (NfL), glial fibrillary acidic protein (GFAP), ubiquitin carboxy-terminal hydrolase L1 (UCH-L1), and total tau protein levels. RESULTS: We found that NfL, GFAP, and tau were significantly increased in patients with fatal outcome, while NfL and UCH-L1 in those needing ICU transfer. ROC and Kaplan-Meier curves indicated that total tau levels at admission accurately predict mortality. CONCLUSIONS: Blood neural markers may provide additional prognostic value to conventional biomarkers used to predict COVID-19 outcome. |*COVID-19/mortality[MESH] |*Intermediate Filaments[MESH] |Biomarkers[MESH] |Glial Fibrillary Acidic Protein/blood[MESH] |Humans[MESH] |Neurofilament Proteins/*blood[MESH] |Ubiquitin Thiolesterase/blood[MESH]Blood neurofilament light chain and total tau levels at admission pred(epmc).pdf DeepDyve Pubget Overpricing